2-NPPA Mitigates Osteoclastogenesis via Reducing TRAF6-Mediated c-fos Expression

2-NPPA Mitigates Osteoclastogenesis via Reducing TRAF6-Mediated c-fos Expression

Excessive bone resorption leads to bone destruction in pathological bone diseases. Osteoporosis, which occurs when osteoclast-mediated bone resorption exceeds osteoblast-mediated bone synthesis, is regarded a global health challenge. Therefore, it is of great importance to identify agents that can r...

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Bibliographic Details
Main Authors: Zhihao Chen, Mina Ding, Eunjin Cho, Jihyoun Seong, Sunwoo Lee, Tae-Hoon Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
acetamide
osteoclastogenesis
bone loss
c-fos
TRAF6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.599081/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.599081/full

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