Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage
Most lung disorders are known to be associated to considerable modifications of surfactant composition. Numerous of these abnormalities have been exploited in the past to diagnose lung diseases, allowing proper treatment and follow-up. Diagnosis was then based on phospholipid content, surface tensio...
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Online Access: | http://dx.doi.org/10.1155/2001/607263 |
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doaj-9ce46ae2d60b4a81b0f7eb80cce5c35c2020-11-24T23:17:00ZengHindawi LimitedDisease Markers0278-02401875-86302001-01-0117427128410.1155/2001/607263Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar LavageIsabelle Noël-Georis0A. Bernard1Paul Falmagne2Ruddy Wattiez3Laboratoire de Chimie Biologique, Université de Mons-Hainaut, avenue du Champ de Mars 6, B-7000 Mons, BelgiumUnite de Toxicologie Industrielle et de Médecine du Travail, Université Catholique de Louvain, Clos Chapelle-aux-Champs, B-1200 Bruxelles, BelgiumLaboratoire de Chimie Biologique, Université de Mons-Hainaut, avenue du Champ de Mars 6, B-7000 Mons, BelgiumLaboratoire de Chimie Biologique, Université de Mons-Hainaut, avenue du Champ de Mars 6, B-7000 Mons, BelgiumMost lung disorders are known to be associated to considerable modifications of surfactant composition. Numerous of these abnormalities have been exploited in the past to diagnose lung diseases, allowing proper treatment and follow-up. Diagnosis was then based on phospholipid content, surface tension and cytological features of the epithelial lining fluid (ELF), sampled by bronchoalveolar lavage (BAL) during fiberoscopic bronchoscopy. Today, it appears that the protein content of ELF displays a remarkably high complexity, not only due to the wide variety of the proteins it contains but also because of the great diversity of their cellular origins. The significance of the use of proteome analysis of BAL fluid for the search for new lung disease marker proteins and for their simultaneous display and analysis in patients suffering from lung disorders has been examined.http://dx.doi.org/10.1155/2001/607263 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabelle Noël-Georis A. Bernard Paul Falmagne Ruddy Wattiez |
spellingShingle |
Isabelle Noël-Georis A. Bernard Paul Falmagne Ruddy Wattiez Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage Disease Markers |
author_facet |
Isabelle Noël-Georis A. Bernard Paul Falmagne Ruddy Wattiez |
author_sort |
Isabelle Noël-Georis |
title |
Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage |
title_short |
Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage |
title_full |
Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage |
title_fullStr |
Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage |
title_full_unstemmed |
Proteomics as the Tool to Search for Lung Disease Markers in Bronchoalveolar Lavage |
title_sort |
proteomics as the tool to search for lung disease markers in bronchoalveolar lavage |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2001-01-01 |
description |
Most lung disorders are known to be associated to considerable modifications of surfactant composition. Numerous of these abnormalities have been exploited in the past to diagnose lung diseases, allowing proper treatment and follow-up. Diagnosis was then based on phospholipid content, surface tension and cytological features of the epithelial lining fluid (ELF), sampled by bronchoalveolar lavage (BAL) during fiberoscopic bronchoscopy. Today, it appears that the protein content of ELF displays a remarkably high complexity, not only due to the wide variety of the proteins it contains but also because of the great diversity of their cellular origins. The significance of the use of proteome analysis of BAL fluid for the search for new lung disease marker proteins and for their simultaneous display and analysis in patients suffering from lung disorders has been examined. |
url |
http://dx.doi.org/10.1155/2001/607263 |
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