LTβR Signaling Controls Lymphatic Migration of Immune Cells

LTβR Signaling Controls Lymphatic Migration of Immune Cells

The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate...

Full description

Bibliographic Details
Main Authors: Wenji Piao, Vivek Kasinath, Vikas Saxena, Ram Lakhan, Jegan Iyyathurai, Jonathan S. Bromberg
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
lymphotoxin
lymphotoxin β receptor signaling
Treg migration
non-canonical nuclear factor κB pathway
lymphatic endothelial cells
Online Access:https://www.mdpi.com/2073-4409/10/4/747
id doaj-9cece2f1127443e481c899c184d0da12
record_format Article
spelling doaj-9cece2f1127443e481c899c184d0da122021-03-29T23:00:29ZengMDPI AGCells2073-44092021-03-011074774710.3390/cells10040747LTβR Signaling Controls Lymphatic Migration of Immune CellsWenji Piao0Vivek Kasinath1Vikas Saxena2Ram Lakhan3Jegan Iyyathurai4Jonathan S. Bromberg5Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USARenal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USACenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USACenter for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USAThe pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival.https://www.mdpi.com/2073-4409/10/4/747lymphotoxinlymphotoxin β receptor signalingTreg migrationnon-canonical nuclear factor κB pathwaylymphatic endothelial cells
collection DOAJ
language English
format Article
sources DOAJ
author Wenji Piao
Vivek Kasinath
Vikas Saxena
Ram Lakhan
Jegan Iyyathurai
Jonathan S. Bromberg
spellingShingle Wenji Piao
Vivek Kasinath
Vikas Saxena
Ram Lakhan
Jegan Iyyathurai
Jonathan S. Bromberg
LTβR Signaling Controls Lymphatic Migration of Immune Cells
Cells
lymphotoxin
lymphotoxin β receptor signaling
Treg migration
non-canonical nuclear factor κB pathway
lymphatic endothelial cells
author_facet Wenji Piao
Vivek Kasinath
Vikas Saxena
Ram Lakhan
Jegan Iyyathurai
Jonathan S. Bromberg
author_sort Wenji Piao
title LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_short LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_full LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_fullStr LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_full_unstemmed LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_sort ltβr signaling controls lymphatic migration of immune cells
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-03-01
description The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival.
topic lymphotoxin
lymphotoxin β receptor signaling
Treg migration
non-canonical nuclear factor κB pathway
lymphatic endothelial cells
url https://www.mdpi.com/2073-4409/10/4/747
work_keys_str_mv AT wenjipiao ltbrsignalingcontrolslymphaticmigrationofimmunecells
AT vivekkasinath ltbrsignalingcontrolslymphaticmigrationofimmunecells
AT vikassaxena ltbrsignalingcontrolslymphaticmigrationofimmunecells
AT ramlakhan ltbrsignalingcontrolslymphaticmigrationofimmunecells
AT jeganiyyathurai ltbrsignalingcontrolslymphaticmigrationofimmunecells
AT jonathansbromberg ltbrsignalingcontrolslymphaticmigrationofimmunecells
_version_ 1724190351593308160

Similar Items