Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile That Impacts Overall Survival

Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile That Impacts Overall Survival

Mucins are commonly associated with pancreatic ductal adenocarcinoma (PDAC) that is a deadly disease because of the lack of early diagnosis and efficient therapies. There are 22 mucin genes encoding large <i>O</i>-glycoproteins divided into two major subgroups: membrane-bound and secrete...

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Bibliographic Details
Main Authors: Nicolas Jonckheere, Julie Auwercx, Elsa Hadj Bachir, Lucie Coppin, Nihad Boukrout, Audrey Vincent, Bernadette Neve, Mathieu Gautier, Victor Treviño, Isabelle Van Seuningen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
pancreatic cancer
TCGA
mucin
gene signature
unsupervised hierarchical clustering
overall survival
Online Access:https://www.mdpi.com/2072-6694/12/11/3309

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