Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma
Haiyan Fan,1 Cuiju Wang,2 Zhanjun Guo11Department of Gastroenterology and Hepatology, 2Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of ChinaObjective: Single nucleotide polymorphisms (SNPs) accumulated frequently in th...
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doaj-9cf82802ce4f45bb83d33369ba3b7e4c2020-11-25T00:21:06ZengDove Medical PressOncoTargets and Therapy1178-69302013-08-012013default10411045Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphomaFan HWang CGuo ZHaiyan Fan,1 Cuiju Wang,2 Zhanjun Guo11Department of Gastroenterology and Hepatology, 2Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of ChinaObjective: Single nucleotide polymorphisms (SNPs) accumulated frequently in the mitochondrial displacement loop (D-loop) in many cancers. We had identified cancer risk-associated SNPs in the D-loop of non-Hodgkin lymphoma (NHL) patients previously, in this study, we investigated the association of age at onset and D-loop SNPs in NHL patients.Materials and methods: The D-loop region of mtDNA was sequenced for 133 NHL patients recorded at the Fourth Hospital of Hebei Medical University. The Kaplan-Meier method was used to identify age at onset-associated SNPs in the D-loop of NHL patients. The Cox proportional hazards model was used to identify independent risk factors for age at onset.Results: The SNP sites of nucleotides 146C/T, 151T/C, 194T/C, 315C/C insert, 523Del/A, and 525Del/C were identified for their association with age at onset, by the logrank test. In an overall multivariate analysis, allele 146 (relative risk, 0.403; 95% confidence interval [CI]: 0.182-0.895) (P = 0.026), allele 151 (relative risk, 0.378; 95% CI: 0.165-0.868) (P = 0.022), and allele 315 (relative risk, 3.554; 95% CI: 1.344-9.400) (P = 0.011) were identified as independent predictors for age at onset in NHL patients.Conclusion: SNPs in the D-loop can predict age at onset in NHL patients. Analysis of the D-loop SNPs can help identify NHL patient subgroups at high risk of early onset.Keywords: Kaplan–Meier; Cox proportional hazards model, D-loop, single nucleotide polymorphismshttp://www.dovepress.com/single-nucleotide-polymorphisms-in-the-mitochondrial-displacement-loop-a13881 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fan H Wang C Guo Z |
spellingShingle |
Fan H Wang C Guo Z Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma OncoTargets and Therapy |
author_facet |
Fan H Wang C Guo Z |
author_sort |
Fan H |
title |
Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma |
title_short |
Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma |
title_full |
Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma |
title_fullStr |
Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma |
title_full_unstemmed |
Single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-Hodgkin lymphoma |
title_sort |
single nucleotide polymorphisms in the mitochondrial displacement loop and age at onset of non-hodgkin lymphoma |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2013-08-01 |
description |
Haiyan Fan,1 Cuiju Wang,2 Zhanjun Guo11Department of Gastroenterology and Hepatology, 2Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of ChinaObjective: Single nucleotide polymorphisms (SNPs) accumulated frequently in the mitochondrial displacement loop (D-loop) in many cancers. We had identified cancer risk-associated SNPs in the D-loop of non-Hodgkin lymphoma (NHL) patients previously, in this study, we investigated the association of age at onset and D-loop SNPs in NHL patients.Materials and methods: The D-loop region of mtDNA was sequenced for 133 NHL patients recorded at the Fourth Hospital of Hebei Medical University. The Kaplan-Meier method was used to identify age at onset-associated SNPs in the D-loop of NHL patients. The Cox proportional hazards model was used to identify independent risk factors for age at onset.Results: The SNP sites of nucleotides 146C/T, 151T/C, 194T/C, 315C/C insert, 523Del/A, and 525Del/C were identified for their association with age at onset, by the logrank test. In an overall multivariate analysis, allele 146 (relative risk, 0.403; 95% confidence interval [CI]: 0.182-0.895) (P = 0.026), allele 151 (relative risk, 0.378; 95% CI: 0.165-0.868) (P = 0.022), and allele 315 (relative risk, 3.554; 95% CI: 1.344-9.400) (P = 0.011) were identified as independent predictors for age at onset in NHL patients.Conclusion: SNPs in the D-loop can predict age at onset in NHL patients. Analysis of the D-loop SNPs can help identify NHL patient subgroups at high risk of early onset.Keywords: Kaplan–Meier; Cox proportional hazards model, D-loop, single nucleotide polymorphisms |
url |
http://www.dovepress.com/single-nucleotide-polymorphisms-in-the-mitochondrial-displacement-loop-a13881 |
work_keys_str_mv |
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