Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) mod...
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doaj-9cf8c46008e6493fbe3859f66c38e9a82020-11-25T02:23:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-02-011010.3389/fonc.2020.00161519856Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST ImagingLorena Consolino0Lorena Consolino1Annasofia Anemone2Martina Capozza3Antonella Carella4Pietro Irrera5Alessia Corrado6Chetan Dhakan7Chetan Dhakan8Martina Bracesco9Dario Livio Longo10Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, GermanyDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, ItalyInstitute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, ItalyUniversity of Campania “Luigi Vanvitelli”, Naples, ItalyInstitute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, ItalyInstitute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, ItalyUniversity of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, ItalyInstitute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, ItalyAltered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.https://www.frontiersin.org/article/10.3389/fonc.2020.00161/fulltumor metabolismtumor acidosisCEST-MRIimagingtherapytumor pH |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lorena Consolino Lorena Consolino Annasofia Anemone Martina Capozza Antonella Carella Pietro Irrera Alessia Corrado Chetan Dhakan Chetan Dhakan Martina Bracesco Dario Livio Longo |
spellingShingle |
Lorena Consolino Lorena Consolino Annasofia Anemone Martina Capozza Antonella Carella Pietro Irrera Alessia Corrado Chetan Dhakan Chetan Dhakan Martina Bracesco Dario Livio Longo Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging Frontiers in Oncology tumor metabolism tumor acidosis CEST-MRI imaging therapy tumor pH |
author_facet |
Lorena Consolino Lorena Consolino Annasofia Anemone Martina Capozza Antonella Carella Pietro Irrera Alessia Corrado Chetan Dhakan Chetan Dhakan Martina Bracesco Dario Livio Longo |
author_sort |
Lorena Consolino |
title |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging |
title_short |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging |
title_full |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging |
title_fullStr |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging |
title_full_unstemmed |
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging |
title_sort |
non-invasive investigation of tumor metabolism and acidosis by mri-cest imaging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-02-01 |
description |
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique. |
topic |
tumor metabolism tumor acidosis CEST-MRI imaging therapy tumor pH |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00161/full |
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