A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these...

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Main Authors: Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, Tannishtha Reya
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19782-x
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spelling doaj-9cff1956974c4fd4bec74dfa1770589a2021-05-11T09:00:31ZengNature Publishing GroupNature Communications2041-17232020-11-0111111510.1038/s41467-020-19782-xA stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemiaKyle Spinler0Jeevisha Bajaj1Takahiro Ito2Bryan Zimdahl3Michael Hamilton4Armin Ahmadi5Claire S. Koechlein6Nikki Lytle7Hyog Young Kwon8Ferdous Anower-E-Khuda9Hao Sun10Allen Blevins11Joi Weeks12Marcie Kritzik13Jan Karlseder14Mark H. Ginsberg15Pyong Woo Park16Jeffrey D. Esko17Tannishtha Reya18Department of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Cellular and Molecular Medicine, University of California San Diego School of MedicineDepartment of Medicine, University of California San DiegoDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineSalk InstituteDepartment of Medicine, University of California San DiegoDepartment of Medicine, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Cellular and Molecular Medicine, University of California San Diego School of MedicineDepartment of Pharmacology, University of California San Diego School of MedicineIdentifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.https://doi.org/10.1038/s41467-020-19782-x
collection DOAJ
language English
format Article
sources DOAJ
author Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
spellingShingle Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
Nature Communications
author_facet Kyle Spinler
Jeevisha Bajaj
Takahiro Ito
Bryan Zimdahl
Michael Hamilton
Armin Ahmadi
Claire S. Koechlein
Nikki Lytle
Hyog Young Kwon
Ferdous Anower-E-Khuda
Hao Sun
Allen Blevins
Joi Weeks
Marcie Kritzik
Jan Karlseder
Mark H. Ginsberg
Pyong Woo Park
Jeffrey D. Esko
Tannishtha Reya
author_sort Kyle Spinler
title A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_short A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_full A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_fullStr A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_full_unstemmed A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
title_sort stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.
url https://doi.org/10.1038/s41467-020-19782-x
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