Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.
Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in yo...
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doaj-9d061029a0304ac48f86863adfd67f4b2020-11-25T01:32:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8742110.1371/journal.pone.0087421Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.Julie SauvantJean-Christophe DelpechKarine PalinNadia De MotaJennifer DuditAgnès AubertHélène OrcelPascale RouxSophie LayéFrançoise MoosCatherine Llorens-CortesAgnès NadjarNormal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. The overactivity of vasopressin neurons was sustained partly by the increased expression of Transient receptor potential vanilloid2 (Trpv2), because central Trpv blocker injection reversed the age-induced increase in plasma vasopressin concentration without modifying plasma apelin concentration. The morphofunctional plasticity of the supraoptic nucleus neuron-astrocyte network normally observed during chronic dehydration in adults appeared to be impaired in aged rats as well. IL-6 overproduction by astrocytes and low-grade microglial neuroinflammation may contribute to the modification of neuronal functioning during aging. Indeed, central treatment with antibodies against IL-6 decreased plasma vasopressin levels and increased plasma apelin concentration toward the values observed in younger adults. Conversely, minocycline treatment (inhibiting microglial metabolism) did not affect plasma vasopressin concentration, but increased plasma apelin concentration toward control values for younger adults. This study is the first to demonstrate dual vasopressin/apelin adaptation mediated by inflammatory molecules and neuronal Trpv2, during aging.http://europepmc.org/articles/PMC3914823?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Sauvant Jean-Christophe Delpech Karine Palin Nadia De Mota Jennifer Dudit Agnès Aubert Hélène Orcel Pascale Roux Sophie Layé Françoise Moos Catherine Llorens-Cortes Agnès Nadjar |
spellingShingle |
Julie Sauvant Jean-Christophe Delpech Karine Palin Nadia De Mota Jennifer Dudit Agnès Aubert Hélène Orcel Pascale Roux Sophie Layé Françoise Moos Catherine Llorens-Cortes Agnès Nadjar Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. PLoS ONE |
author_facet |
Julie Sauvant Jean-Christophe Delpech Karine Palin Nadia De Mota Jennifer Dudit Agnès Aubert Hélène Orcel Pascale Roux Sophie Layé Françoise Moos Catherine Llorens-Cortes Agnès Nadjar |
author_sort |
Julie Sauvant |
title |
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
title_short |
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
title_full |
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
title_fullStr |
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
title_full_unstemmed |
Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
title_sort |
mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. The overactivity of vasopressin neurons was sustained partly by the increased expression of Transient receptor potential vanilloid2 (Trpv2), because central Trpv blocker injection reversed the age-induced increase in plasma vasopressin concentration without modifying plasma apelin concentration. The morphofunctional plasticity of the supraoptic nucleus neuron-astrocyte network normally observed during chronic dehydration in adults appeared to be impaired in aged rats as well. IL-6 overproduction by astrocytes and low-grade microglial neuroinflammation may contribute to the modification of neuronal functioning during aging. Indeed, central treatment with antibodies against IL-6 decreased plasma vasopressin levels and increased plasma apelin concentration toward the values observed in younger adults. Conversely, minocycline treatment (inhibiting microglial metabolism) did not affect plasma vasopressin concentration, but increased plasma apelin concentration toward control values for younger adults. This study is the first to demonstrate dual vasopressin/apelin adaptation mediated by inflammatory molecules and neuronal Trpv2, during aging. |
url |
http://europepmc.org/articles/PMC3914823?pdf=render |
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