Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study
Abstract Background The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). Methods This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points:...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-08-01
|
Series: | BMC Psychiatry |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12888-017-1405-0 |
id |
doaj-9d07107ca439484f9e4d78ccc74a5e01 |
---|---|
record_format |
Article |
spelling |
doaj-9d07107ca439484f9e4d78ccc74a5e012020-11-25T02:47:15ZengBMCBMC Psychiatry1471-244X2017-08-011711610.1186/s12888-017-1405-0Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort studyYingchun Zeng0Yingtao Li1Huaan Xia2Shenglan Wang3Jingxuan Zhou4Dunjin Chen5Research Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityResearch Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityResearch Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityZhujiang Hospital of Southern Medical UniversityDepartment of Obstetrics, Qingdao Municipal HospitalResearch Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical UniversityAbstract Background The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). Methods This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregnancy (T1), after delivery at week one (T2), and after delivery week six (T3) using a set of self-reported questionnaires and blood sample assays. Results A total of 156 subjects were included for data analysis. The prevalence of anxiety symptoms ranged from 32.69% to 36.53%. The prevalence of PPD was also high and ranged from 27.56% to 35.89%. In the third trimester, significant predictors of depressive symptoms include serum retinol-binding protein (RBP) concentrations and estradiol levels (P = 0.008 and 0.033, respectively). At one week after delivery, serum concentrations of RBP at T2 were still significant predictors of depressive symptoms (P = 0.020, and serum estradiol concentrations at T1 were a significant predictor (P = 0.010). The most stable predictor of depressive symptoms at T3 was anxiety symptoms, especially at T3 time point (P < 0.001). Serum RBP concentrations at T1 and T2 were still significant predictors of depressive symptoms at T3. Conclusion A high prevalence of anxiety and depressive symptoms tended to persist in Chinese women during the peripartum period. This study, which found the potential contribution of RBP to the occurrence of PPD, requires that large sample studies be conducted in future with a longer-term follow-up period, in order to confirm its results.http://link.springer.com/article/10.1186/s12888-017-1405-0RetinoidsRetinol-binding proteinPeripartum depressionChinese women |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yingchun Zeng Yingtao Li Huaan Xia Shenglan Wang Jingxuan Zhou Dunjin Chen |
spellingShingle |
Yingchun Zeng Yingtao Li Huaan Xia Shenglan Wang Jingxuan Zhou Dunjin Chen Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study BMC Psychiatry Retinoids Retinol-binding protein Peripartum depression Chinese women |
author_facet |
Yingchun Zeng Yingtao Li Huaan Xia Shenglan Wang Jingxuan Zhou Dunjin Chen |
author_sort |
Yingchun Zeng |
title |
Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study |
title_short |
Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study |
title_full |
Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study |
title_fullStr |
Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study |
title_full_unstemmed |
Retinoids, anxiety and peripartum depressive symptoms among Chinese women: a prospective cohort study |
title_sort |
retinoids, anxiety and peripartum depressive symptoms among chinese women: a prospective cohort study |
publisher |
BMC |
series |
BMC Psychiatry |
issn |
1471-244X |
publishDate |
2017-08-01 |
description |
Abstract Background The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). Methods This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregnancy (T1), after delivery at week one (T2), and after delivery week six (T3) using a set of self-reported questionnaires and blood sample assays. Results A total of 156 subjects were included for data analysis. The prevalence of anxiety symptoms ranged from 32.69% to 36.53%. The prevalence of PPD was also high and ranged from 27.56% to 35.89%. In the third trimester, significant predictors of depressive symptoms include serum retinol-binding protein (RBP) concentrations and estradiol levels (P = 0.008 and 0.033, respectively). At one week after delivery, serum concentrations of RBP at T2 were still significant predictors of depressive symptoms (P = 0.020, and serum estradiol concentrations at T1 were a significant predictor (P = 0.010). The most stable predictor of depressive symptoms at T3 was anxiety symptoms, especially at T3 time point (P < 0.001). Serum RBP concentrations at T1 and T2 were still significant predictors of depressive symptoms at T3. Conclusion A high prevalence of anxiety and depressive symptoms tended to persist in Chinese women during the peripartum period. This study, which found the potential contribution of RBP to the occurrence of PPD, requires that large sample studies be conducted in future with a longer-term follow-up period, in order to confirm its results. |
topic |
Retinoids Retinol-binding protein Peripartum depression Chinese women |
url |
http://link.springer.com/article/10.1186/s12888-017-1405-0 |
work_keys_str_mv |
AT yingchunzeng retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy AT yingtaoli retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy AT huaanxia retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy AT shenglanwang retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy AT jingxuanzhou retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy AT dunjinchen retinoidsanxietyandperipartumdepressivesymptomsamongchinesewomenaprospectivecohortstudy |
_version_ |
1724753839440003072 |