Síntese da fenitoína assistida por micro-ondas: proposta de aula prática para alunos de graduação

• Main Authors: Eduardo L. Konrath, Maristela Piedade, Vera Lucia Eifler-Lima
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2012-01-01
• Series: Química Nova
• Subjects: drug synthesis; phenytoin; microwave-assisted organic synthesis
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000900033&lng=en&tlng=en

Microwave synthesis is considered a breakthrough in the field of chemistry due to its benefits over conventional heating methods. We describe, for the first time, the total synthesis of phenytoin adapted for a microwave reactor, proposed as an experiment for undergraduate courses. When carried out with microwaves, the synthetic route provided phenytoin in 6 min and 30 s, while for conventional heating the total time was 170 min. The experiment also involves rapid identification of compounds by TLC, ¹H NMR, FT-IR and melting points determination.