Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant
Rationale: Intravenous administration of Glutamine dipeptides (Gln) has been proposed as treatment of oral mucositis following a bone marrow transplant (BMT). Objective: To establish the effects of intravenous Gln supplementation upon the severity of oral mucositis after BMT. Study design: Retros...
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Asociación Para el Progreso de la Biomedicina
2018-04-01
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Online Access: | https://www.jonnpr.com/pdf/2251.pdf |
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doaj-9d1e268b934d45a4a48be5c87005f5722020-11-25T00:26:41ZengAsociación Para el Progreso de la BiomedicinaJounal of Negative and No Positive Results2529-850X2529-850X2018-04-013427928710.19230/jonnpr.2251Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplantMaría Belén Andrade Hernández0Marcela Alejandra Chaug Solórzano1Francisco Xavier Andino Rodríguez2Víctor Hugo Sierra Nieto3Dolores Rodríguez Veintimilla4Licenciada en Nutrición, Dietética y Estética. Carrera de Nutrición, Dietética y Estética Facultad de Ciencias Médicas Universidad Católica de Santiago de Guayaquil. Guayaquil. EcuadorLicenciada en Nutrición, Dietética y Estética. Carrera de Nutrición, Dietética y Estética Facultad de Ciencias Médicas Universidad Católica de Santiago de Guayaquil. Guayaquil. EcuadorMédico, Especialista de Primer Grado en Neurología. Máster En Epidemiología con mención en la atención del VIH/SIDA. Carrera de Nutrición, Dietética y Estética Facultad de Ciencias Médicas Universidad Católica de Santiago de Guayaquil. Guayaquil. EcuadorEconomista. Magister en Ciencias Económicas. Docente. Carrera de Nutrición, Dietética y Estética Facultad de Ciencias Médicas Universidad Católica de Santiago de Guayaquil. Guayaquil. EcuadorMédico. Departamento de Nutrición Clínica Hospital Oncológico SOLCA Sociedad de Lucha Contra el Cáncer. Guayaquil. EcuadorRationale: Intravenous administration of Glutamine dipeptides (Gln) has been proposed as treatment of oral mucositis following a bone marrow transplant (BMT). Objective: To establish the effects of intravenous Gln supplementation upon the severity of oral mucositis after BMT. Study design: Retrospective, analytical. Study serie: Records from 25 patients (Males: 56.0%; BMT cause: Leukemia: 64.0%) who developed oral mucositis (Grades III – IV: 48.0%) after BMT (Autologous: 44.0%) at the "Juan Tanca Marengo" Hospital (Guayaquil, Ecuador) between 2009 – 2017. Glutamine source: Dipeptiven©®: 13 grams of Gln suspended in 100 milliliters of a 20% solution of the alanine-glutamine dipeptide (Fresenius-Kabi©®, Germany). Materials and Methods: Gln-treated patients received 3(4.0% of the treatment leg), 5 (20.0%); 6 (12.0%); 7 (48.0%); or 10 (16.0%) doses of the dipeptide until resolution of the symptoms. Impact of Gln was estimated from changes observed in the severity and duration of mucositis, white blood cell counts, and body weight regarding 25 non-Gln treated patients (Males: 68.0%; Leukemias: 32.0%; Autologous graft: 68.0%; Grade III – IV mucositis: 48.0%). Results: Intravenously-administered Gln shortened duration of oral mucositis: Gln-Treated: 12.5 ± 5.1 days vs. Non-Gln Treated: 21.3 ± 17.8 days (p < 0.05). Also, intravenous Gln marginally ameliorated loss of body weight: Gln-Treated -4.5 ± 5.5% vs. Non-Gln Treated: -7.5 ± 5.7% (p = 0.07). Conclusions: Intravenous Gln administration shortens duration of oral mucositis following BMT. Gln effect might be translated to a lesser weight loss in patients with oral mucositis. https://www.jonnpr.com/pdf/2251.pdfmucositisglutaminebone marrow transplant; chemotherapyradiotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María Belén Andrade Hernández Marcela Alejandra Chaug Solórzano Francisco Xavier Andino Rodríguez Víctor Hugo Sierra Nieto Dolores Rodríguez Veintimilla |
spellingShingle |
María Belén Andrade Hernández Marcela Alejandra Chaug Solórzano Francisco Xavier Andino Rodríguez Víctor Hugo Sierra Nieto Dolores Rodríguez Veintimilla Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant Jounal of Negative and No Positive Results mucositis glutamine bone marrow transplant ; chemotherapy radiotherapy |
author_facet |
María Belén Andrade Hernández Marcela Alejandra Chaug Solórzano Francisco Xavier Andino Rodríguez Víctor Hugo Sierra Nieto Dolores Rodríguez Veintimilla |
author_sort |
María Belén Andrade Hernández |
title |
Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
title_short |
Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
title_full |
Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
title_fullStr |
Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
title_full_unstemmed |
Intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
title_sort |
intravenous glutamine does not modify leucocyte count but shortens duration of mucositis after bone marrow transplant |
publisher |
Asociación Para el Progreso de la Biomedicina |
series |
Jounal of Negative and No Positive Results |
issn |
2529-850X 2529-850X |
publishDate |
2018-04-01 |
description |
Rationale: Intravenous administration of Glutamine dipeptides (Gln) has been proposed as treatment of oral mucositis following a bone marrow transplant (BMT).
Objective: To establish the effects of intravenous Gln supplementation upon the severity of oral mucositis after BMT. Study design: Retrospective, analytical. Study serie: Records from 25 patients (Males: 56.0%; BMT cause: Leukemia: 64.0%) who developed oral mucositis (Grades III – IV: 48.0%) after BMT (Autologous: 44.0%) at the "Juan Tanca Marengo" Hospital (Guayaquil, Ecuador) between 2009 – 2017. Glutamine source: Dipeptiven©®: 13 grams of Gln suspended in 100 milliliters of a 20% solution of the alanine-glutamine dipeptide (Fresenius-Kabi©®, Germany).
Materials and Methods: Gln-treated patients received 3(4.0% of the treatment leg), 5 (20.0%); 6 (12.0%); 7 (48.0%); or 10 (16.0%) doses of the dipeptide until resolution of the symptoms. Impact of Gln was estimated from changes observed in the severity and duration of mucositis, white blood cell counts, and body weight regarding 25 non-Gln treated patients (Males: 68.0%; Leukemias: 32.0%; Autologous graft: 68.0%; Grade III – IV mucositis: 48.0%).
Results: Intravenously-administered Gln shortened duration of oral mucositis: Gln-Treated: 12.5 ± 5.1 days vs. Non-Gln Treated: 21.3
± 17.8 days (p < 0.05). Also, intravenous Gln marginally ameliorated loss of body weight: Gln-Treated -4.5 ± 5.5% vs. Non-Gln Treated: -7.5 ± 5.7% (p = 0.07).
Conclusions: Intravenous Gln administration shortens duration of oral mucositis following BMT. Gln effect might be translated to a lesser weight loss in patients with oral mucositis.
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topic |
mucositis glutamine bone marrow transplant ; chemotherapy radiotherapy |
url |
https://www.jonnpr.com/pdf/2251.pdf |
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