Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

Summary: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability. Here, we provide evidence that Mertk, a gene highly expressed by microglia that alters MS risk, is required for efficient remyelinatio...

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Bibliographic Details
Main Authors: Kimberle Shen, Mike Reichelt, Roxanne V. Kyauk, Hai Ngu, Yun-An A. Shen, Oded Foreman, Zora Modrusan, Brad A. Friedman, Morgan Sheng, Tracy J. Yuen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
remyelination
demyelination
Mertk
IFNγ
microglia
oligodendrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001492

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