A molecular switch regulating transcriptional repression and activation of PPARγ

Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse...

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Main Authors:	Jinsai Shang, Sarah A. Mosure, Jie Zheng, Richard Brust, Jared Bass, Ashley Nichols, Laura A. Solt, Patrick R. Griffin, Douglas J. Kojetin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14750-x

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spelling	doaj-9d32e7db99b24a56b787934b31a561302021-05-11T08:56:39ZengNature Publishing GroupNature Communications2041-17232020-02-0111111410.1038/s41467-020-14750-xA molecular switch regulating transcriptional repression and activation of PPARγJinsai Shang0Sarah A. Mosure1Jie Zheng2Richard Brust3Jared Bass4Ashley Nichols5Laura A. Solt6Patrick R. Griffin7Douglas J. Kojetin8Department of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteSummer Undergraduate Research Fellows (SURF) program, The Scripps Research InstituteDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteStructural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation, where helix 12 is located within the orthosteric ligand-binding pocket instead, and discuss mechanistic implications.https://doi.org/10.1038/s41467-020-14750-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin
spellingShingle	Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin A molecular switch regulating transcriptional repression and activation of PPARγ Nature Communications
author_facet	Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin
author_sort	Jinsai Shang
title	A molecular switch regulating transcriptional repression and activation of PPARγ
title_short	A molecular switch regulating transcriptional repression and activation of PPARγ
title_full	A molecular switch regulating transcriptional repression and activation of PPARγ
title_fullStr	A molecular switch regulating transcriptional repression and activation of PPARγ
title_full_unstemmed	A molecular switch regulating transcriptional repression and activation of PPARγ
title_sort	molecular switch regulating transcriptional repression and activation of pparγ
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation, where helix 12 is located within the orthosteric ligand-binding pocket instead, and discuss mechanistic implications.
url	https://doi.org/10.1038/s41467-020-14750-x
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A molecular switch regulating transcriptional repression and activation of PPARγ

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