The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line

The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line

Leflunomide, an anti-inflammatory agent, has been shown to be effective in multiple myeloma (MM) treatment; however, the mechanism of this phenomenon has not been fully elucidated. The aim of the study was to assess the role of mitochondria and dihydroorotate dehydrogenase (DHODH) inhibition in the...

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Bibliographic Details
Main Authors: Grzegorz Adamczuk, Ewelina Humeniuk, Magdalena Iwan, Dorota Natorska-Chomicka, Kamila Adamczuk, Agnieszka Korga-Plewko
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
leflunomide
teriflunomide
multiple myeloma
dehydrogenase dihydroorotate
protein tyrosine kinases
mitochondria
Online Access:https://www.mdpi.com/1420-3049/26/18/5653

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https://www.mdpi.com/1420-3049/26/18/5653

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