Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.
Withaferin A (WFA) is a natural product that binds to soluble forms of the type III intermediate filament (IF) vimentin. Currently, it is unknown under what pathophysiological contexts vimentin is druggable, as cytoskeltal vimentin-IFs are abundantly expressed. To investigate druggability of vimenti...
Main Authors: | Paola Bargagna-Mohan, Sunil P Deokule, Kyle Thompson, John Wizeman, Cidambi Srinivasan, Sunil Vooturi, Uday B Kompella, Royce Mohan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667686/?tool=EBI |
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