CELULLAR DRUGS TRANSPORTERS. THE JOURNEY OF THE ORAL ANTIDIABETICS AGENTS TROUGH THE ORGANISM

• Main Authors: Héctor Alejandro Serra, Cristian Suárez Cordo, Jorge Alvariñas, Julio César Bragagnolo, Gustavo Daniel Frechtel, Pilar Cean, Claudia Folino, Analía Dagum, Susana Salzberg
• Format: Article
• Language: Spanish
• Published: Sello Editorial Lugones 2018-03-01
• Series: Revista de la Sociedad Argentina de Diabetes
• Subjects: transporte celular de drogas; farmacocinética; antidiabéticos orales
• Online Access: https://www.revistasad.com/index.php/diabetes/article/view/40

Type 2 diabetes mellitus requires multiple pharmacological treatment in order to achieve therapeutic goals and control comorbidities. Therefore, treatment leads to drug interaction. It means that the observed effects, whether therapeutic or adverse, are the result of the concomitant administration of two or more drugs given to a patient. This concept should be extended to foods, cosmetics and environmental substances. For many years, drug interactions were studied in a descriptive-empirical way, but in the last decades the participating mechanisms were hierarchized. Pharmacokinetic interactions involve absorptive, distributive and elimination processes in which enzymes and transport molecules are involved. Nowadays there is an even greater interest in the latter as a source of interactions. The purpose of this paper is to describe the transporters involved in the pharmacokinetics of oral antidiabetic agents , and in this way to realize if there could potentially be any interference when another drug is added.