Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy
Objective: To investigate the regulation of the epidermal growth factor receptor (EGFR) pathway by visfatin and its effect on cardiac hypertrophy. Methods: 60 Wistar male rats were randomly divided into control group, visfatin group and visfatin +AG1478 group, with 20 rats in each group.The cardi...
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doaj-9d4b2b17470f4fb9bf8d8af3f119bdff2021-03-04T08:05:01ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372021-02-01273711Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophyLiang Chang0Yong-Jun Li1Department of Cardiology ,The second hospital of hebei medical university, shijiazhuang 050000Department of Cardiology ,The second hospital of hebei medical university, shijiazhuang 050000Objective: To investigate the regulation of the epidermal growth factor receptor (EGFR) pathway by visfatin and its effect on cardiac hypertrophy. Methods: 60 Wistar male rats were randomly divided into control group, visfatin group and visfatin +AG1478 group, with 20 rats in each group.The cardiac mass index, left ventricular mass index and cardiomyocyte volume of rats in each group were calculated.The total protein content of each group of cardiomyocytes was detected by coomassie bright blue staining, and the protein expression was detected by Western blotting. Results: Compared with the control group, the cardiac mass index, left ventricular mass index, cardiomyocyte volume, protein content, and relative expressions of ANP and BNP were significantly increased in the visfatin group (P<0.05). The relative expression levels of EGFR, p-AKT, p-ERK1/2, p-STAT3, ANP and BNP in cardiac myocytes in the visfatin group were significantly higher than those in the control group and the visfatin+AG1478 group (P<0.05). Conclusion: Visfatin induces hypertrophy in cardiomyocytes by activating the EGFR signaling pathway.http://www.hnykdxxb.com/PDF/202103/02.pdfepidermal growth factor receptor signaling pathwayvisfatincardiomyocyte hypertrophyextracellular signaling kinasesignal transduction and transcription activator 3serine threonine kinase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liang Chang Yong-Jun Li |
spellingShingle |
Liang Chang Yong-Jun Li Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy Journal of Hainan Medical University epidermal growth factor receptor signaling pathway visfatin cardiomyocyte hypertrophy extracellular signaling kinase signal transduction and transcription activator 3 serine threonine kinase |
author_facet |
Liang Chang Yong-Jun Li |
author_sort |
Liang Chang |
title |
Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy |
title_short |
Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy |
title_full |
Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy |
title_fullStr |
Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy |
title_full_unstemmed |
Regulation of the EGFR pathway by visfatin and its effect on cardiac hypertrophy |
title_sort |
regulation of the egfr pathway by visfatin and its effect on cardiac hypertrophy |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2021-02-01 |
description |
Objective: To investigate the regulation of the epidermal growth factor receptor (EGFR)
pathway by visfatin and its effect on cardiac hypertrophy. Methods: 60 Wistar male rats were
randomly divided into control group, visfatin group and visfatin +AG1478 group, with 20
rats in each group.The cardiac mass index, left ventricular mass index and cardiomyocyte
volume of rats in each group were calculated.The total protein content of each group of
cardiomyocytes was detected by coomassie bright blue staining, and the protein expression
was detected by Western blotting. Results: Compared with the control group, the cardiac
mass index, left ventricular mass index, cardiomyocyte volume, protein content, and relative
expressions of ANP and BNP were significantly increased in the visfatin group (P<0.05).
The relative expression levels of EGFR, p-AKT, p-ERK1/2, p-STAT3, ANP and BNP in
cardiac myocytes in the visfatin group were significantly higher than those in the control
group and the visfatin+AG1478 group (P<0.05). Conclusion: Visfatin induces hypertrophy in
cardiomyocytes by activating the EGFR signaling pathway. |
topic |
epidermal growth factor receptor signaling pathway visfatin cardiomyocyte hypertrophy extracellular signaling kinase signal transduction and transcription activator 3 serine threonine kinase |
url |
http://www.hnykdxxb.com/PDF/202103/02.pdf |
work_keys_str_mv |
AT liangchang regulationoftheegfrpathwaybyvisfatinanditseffectoncardiachypertrophy AT yongjunli regulationoftheegfrpathwaybyvisfatinanditseffectoncardiachypertrophy |
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