3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester

3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester

An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is ea...

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Main Authors: Ge Meng, Mei Wang, Ya-Nan Cheng, Kai Chen, Jing Tong, Jie-He Zhang
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molbank
Subjects:
2,3-dihydro-1,3-thiazole
one-pot synthesis
N,N′-diethylthiourea
Online Access:http://www.mdpi.com/1422-8599/2016/4/M919
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spelling doaj-9d50244df1c14906b35ae801d0ab9a502020-11-24T23:14:32ZengMDPI AGMolbank1422-85992016-11-0120164M91910.3390/M919M9193-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl EsterGe Meng0Mei Wang1Ya-Nan Cheng2Kai Chen3Jing Tong4Jie-He Zhang5School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaAn efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%.http://www.mdpi.com/1422-8599/2016/4/M9192,3-dihydro-1,3-thiazoleone-pot synthesisN,N′-diethylthiourea
collection DOAJ
language English
format Article
sources DOAJ
author Ge Meng
Mei Wang
Ya-Nan Cheng
Kai Chen
Jing Tong
Jie-He Zhang
spellingShingle Ge Meng
Mei Wang
Ya-Nan Cheng
Kai Chen
Jing Tong
Jie-He Zhang
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
Molbank
2,3-dihydro-1,3-thiazole
one-pot synthesis
N,N′-diethylthiourea
author_facet Ge Meng
Mei Wang
Ya-Nan Cheng
Kai Chen
Jing Tong
Jie-He Zhang
author_sort Ge Meng
title 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
title_short 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
title_full 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
title_fullStr 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
title_full_unstemmed 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
title_sort 3-ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate ethyl ester
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2016-11-01
description An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%.
topic 2,3-dihydro-1,3-thiazole
one-pot synthesis
N,N′-diethylthiourea
url http://www.mdpi.com/1422-8599/2016/4/M919
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AT meiwang 3ethyl2ethylimino4methyl23dihydro13thiazole5carboxylateethylester
AT yanancheng 3ethyl2ethylimino4methyl23dihydro13thiazole5carboxylateethylester
AT kaichen 3ethyl2ethylimino4methyl23dihydro13thiazole5carboxylateethylester
AT jingtong 3ethyl2ethylimino4methyl23dihydro13thiazole5carboxylateethylester
AT jiehezhang 3ethyl2ethylimino4methyl23dihydro13thiazole5carboxylateethylester
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