3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is ea...
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doaj-9d50244df1c14906b35ae801d0ab9a502020-11-24T23:14:32ZengMDPI AGMolbank1422-85992016-11-0120164M91910.3390/M919M9193-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl EsterGe Meng0Mei Wang1Ya-Nan Cheng2Kai Chen3Jing Tong4Jie-He Zhang5School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, ChinaAn efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%.http://www.mdpi.com/1422-8599/2016/4/M9192,3-dihydro-1,3-thiazoleone-pot synthesisN,N′-diethylthiourea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ge Meng Mei Wang Ya-Nan Cheng Kai Chen Jing Tong Jie-He Zhang |
spellingShingle |
Ge Meng Mei Wang Ya-Nan Cheng Kai Chen Jing Tong Jie-He Zhang 3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester Molbank 2,3-dihydro-1,3-thiazole one-pot synthesis N,N′-diethylthiourea |
author_facet |
Ge Meng Mei Wang Ya-Nan Cheng Kai Chen Jing Tong Jie-He Zhang |
author_sort |
Ge Meng |
title |
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester |
title_short |
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester |
title_full |
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester |
title_fullStr |
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester |
title_full_unstemmed |
3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester |
title_sort |
3-ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate ethyl ester |
publisher |
MDPI AG |
series |
Molbank |
issn |
1422-8599 |
publishDate |
2016-11-01 |
description |
An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%. |
topic |
2,3-dihydro-1,3-thiazole one-pot synthesis N,N′-diethylthiourea |
url |
http://www.mdpi.com/1422-8599/2016/4/M919 |
work_keys_str_mv |
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