ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY

The aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular...

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Main Authors: A. N. Rymashevskii, S. S. Tumanyan, E. M. Frantsiyants, S. V. Tumanyan
Format: Article
Language:Russian
Published: IRBIS LLC 2017-06-01
Series:Акушерство, гинекология и репродукция
Subjects:
Online Access:https://www.gynecology.su/jour/article/view/389
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spelling doaj-9d52ec98ba1d47acbe5c53eb82bb87d12021-07-28T13:44:40ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942017-06-01111141810.17749/2313-7347.2017.11.1.014-018373ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITYA. N. Rymashevskii0S. S. Tumanyan1E. M. Frantsiyants2S. V. Tumanyan3Rostov state medical UniversityRostov state medical UniversityRostov scientific research oncological InstituteRostov scientific research oncological InstituteThe aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular filtration rate were measured.Results. We show that RAAS, along with a systemic inflammatory response, is a key factor in the development of pre-eclampsia and its progression. The increasing level of leptin has a direct damaging effect on the tubular system of the kidneys.Conclusions. Stimulating the RAAS aggravates the inflammatory response and endothelial dysfunction in women with PE and AO. Elevated concen-trations of leptin in these women have a direct damaging impact on the kidney tubules.https://www.gynecology.su/jour/article/view/389pre-eclampsiaobesityleptinrenin-angiotensin-aldosterone systemkidneys.
collection DOAJ
language Russian
format Article
sources DOAJ
author A. N. Rymashevskii
S. S. Tumanyan
E. M. Frantsiyants
S. V. Tumanyan
spellingShingle A. N. Rymashevskii
S. S. Tumanyan
E. M. Frantsiyants
S. V. Tumanyan
ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
Акушерство, гинекология и репродукция
pre-eclampsia
obesity
leptin
renin-angiotensin-aldosterone system
kidneys.
author_facet A. N. Rymashevskii
S. S. Tumanyan
E. M. Frantsiyants
S. V. Tumanyan
author_sort A. N. Rymashevskii
title ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
title_short ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
title_full ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
title_fullStr ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
title_full_unstemmed ENDOCRINE DISFUNCTION IN WOMEN WITH PRE-ECLAMPSIA AND ALIMENTARY OBESITY
title_sort endocrine disfunction in women with pre-eclampsia and alimentary obesity
publisher IRBIS LLC
series Акушерство, гинекология и репродукция
issn 2313-7347
2500-3194
publishDate 2017-06-01
description The aim was to study the renin-angiotensin-aldosterone system (RAAS), the level of leptin and kidney function in women with pre-eclampsia (PE) and alimentary obesity (AO).Materials and methods. The levels of renin, angiotensin II, aldoste-rone, leptin, insulin, cortisol, β2-microglobulin, glomerular filtration rate were measured.Results. We show that RAAS, along with a systemic inflammatory response, is a key factor in the development of pre-eclampsia and its progression. The increasing level of leptin has a direct damaging effect on the tubular system of the kidneys.Conclusions. Stimulating the RAAS aggravates the inflammatory response and endothelial dysfunction in women with PE and AO. Elevated concen-trations of leptin in these women have a direct damaging impact on the kidney tubules.
topic pre-eclampsia
obesity
leptin
renin-angiotensin-aldosterone system
kidneys.
url https://www.gynecology.su/jour/article/view/389
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AT svtumanyan endocrinedisfunctioninwomenwithpreeclampsiaandalimentaryobesity
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