Minocycline in phenotypic models of Huntington's disease
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here, we have tested minocycline in phenotypic...
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doaj-9d530a55c8ed4f0e9423d7b415f633f92021-03-20T04:50:22ZengElsevierNeurobiology of Disease1095-953X2005-02-01181206217Minocycline in phenotypic models of Huntington's diseaseKadiombo Bantubungi0Carine Jacquard1Anita Greco2Annita Pintor3Abdelwahed Chtarto4Khalid Tai5Marie-Christine Galas6Liliane Tenenbaum7Nicole Déglon8Patrizia Popoli9Luisa Minghetti10Emmanuel Brouillet11Jacques Brotchi12Marc Levivier13Serge N. Schiffmann14David Blum15Laboratory of Neurophysiology, ULB-Erasme, Brussels, BelgiumURA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, CEA, Orsay, FranceDepartment of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, ItalyDepartment of Drug Research and Evaluation, Istituto Superiore di Sanita, Roma, ItalyLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; IRIBHM, ULB-Erasme, Brussels, BelgiumLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; IRIBHM, ULB-Erasme, Brussels, BelgiumINSERM U422, Lille, FranceLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; IRIBHM, ULB-Erasme, Brussels, BelgiumDepartment of Medical Research and ImaGene Program, CEA, Orsay, FranceDepartment of Drug Research and Evaluation, Istituto Superiore di Sanita, Roma, ItalyDepartment of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, ItalyURA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, CEA, Orsay, FranceLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; Department of Neurosurgery, ULB-Erasme, Brussels, BelgiumLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; Department of Neurosurgery, ULB-Erasme, Brussels, BelgiumLaboratory of Neurophysiology, ULB-Erasme, Brussels, BelgiumLaboratory of Experimental Neurosurgery, ULB-Erasme, CP602, Bat C-6/113, 808 Route de Lennik, B-1070 Brussels, Belgium; IRIBHM, ULB-Erasme, Brussels, Belgium; Corresponding author. Fax: +32 2 555 46 55.Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here, we have tested minocycline in phenotypic models of HD using 3-nitropropionic acid (3NP) intoxication and quinolinic acid (QA) injections. In the 3NP rat model, where the development of striatal lesions involves calpain, we found that minocycline was not protective, although it attenuated the development of inflammation induced after the onset of striatal degeneration. The lack of minocycline activity on calpain-dependent cell death was also confirmed in vitro using primary striatal cells. Conversely, we found that minocycline reduced lesions and inflammation induced by QA. In cultured cells, minocycline protected against mutated huntingtin and staurosporine, stimulations known to promote caspase-dependent cell death. Altogether, these data suggested that, in HD, minocycline may counteract the development of caspase-dependent neurodegeneration, inflammation, but not calpain-dependent neuronal death.http://www.sciencedirect.com/science/article/pii/S0969996104002311Huntington's disease3-Nitropropionic acidQuinolinic acidMinocyclineStriatumCell death |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kadiombo Bantubungi Carine Jacquard Anita Greco Annita Pintor Abdelwahed Chtarto Khalid Tai Marie-Christine Galas Liliane Tenenbaum Nicole Déglon Patrizia Popoli Luisa Minghetti Emmanuel Brouillet Jacques Brotchi Marc Levivier Serge N. Schiffmann David Blum |
spellingShingle |
Kadiombo Bantubungi Carine Jacquard Anita Greco Annita Pintor Abdelwahed Chtarto Khalid Tai Marie-Christine Galas Liliane Tenenbaum Nicole Déglon Patrizia Popoli Luisa Minghetti Emmanuel Brouillet Jacques Brotchi Marc Levivier Serge N. Schiffmann David Blum Minocycline in phenotypic models of Huntington's disease Neurobiology of Disease Huntington's disease 3-Nitropropionic acid Quinolinic acid Minocycline Striatum Cell death |
author_facet |
Kadiombo Bantubungi Carine Jacquard Anita Greco Annita Pintor Abdelwahed Chtarto Khalid Tai Marie-Christine Galas Liliane Tenenbaum Nicole Déglon Patrizia Popoli Luisa Minghetti Emmanuel Brouillet Jacques Brotchi Marc Levivier Serge N. Schiffmann David Blum |
author_sort |
Kadiombo Bantubungi |
title |
Minocycline in phenotypic models of Huntington's disease |
title_short |
Minocycline in phenotypic models of Huntington's disease |
title_full |
Minocycline in phenotypic models of Huntington's disease |
title_fullStr |
Minocycline in phenotypic models of Huntington's disease |
title_full_unstemmed |
Minocycline in phenotypic models of Huntington's disease |
title_sort |
minocycline in phenotypic models of huntington's disease |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2005-02-01 |
description |
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here, we have tested minocycline in phenotypic models of HD using 3-nitropropionic acid (3NP) intoxication and quinolinic acid (QA) injections. In the 3NP rat model, where the development of striatal lesions involves calpain, we found that minocycline was not protective, although it attenuated the development of inflammation induced after the onset of striatal degeneration. The lack of minocycline activity on calpain-dependent cell death was also confirmed in vitro using primary striatal cells. Conversely, we found that minocycline reduced lesions and inflammation induced by QA. In cultured cells, minocycline protected against mutated huntingtin and staurosporine, stimulations known to promote caspase-dependent cell death. Altogether, these data suggested that, in HD, minocycline may counteract the development of caspase-dependent neurodegeneration, inflammation, but not calpain-dependent neuronal death. |
topic |
Huntington's disease 3-Nitropropionic acid Quinolinic acid Minocycline Striatum Cell death |
url |
http://www.sciencedirect.com/science/article/pii/S0969996104002311 |
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