Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.

INTRODUCTION: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of t...

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Main Authors: André Anjos da Silva, Tani Maria Schilling Ranieri, Fernanda Duarte Torres, Fernanda Sales Luiz Vianna, Graziella Rangel Paniz, Paula Baptista Sanseverino, Paulo Dornelles Picon, Pietro Baptista de Azevedo, Marta Haas Costa, Lavinia Schuler-Faccini, Maria Teresa Vieira Sanseverino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3928255?pdf=render
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spelling doaj-9d63257d75ed4a8e9af96d221520b41f2020-11-25T01:19:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8862410.1371/journal.pone.0088624Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.André Anjos da SilvaTani Maria Schilling RanieriFernanda Duarte TorresFernanda Sales Luiz ViannaGraziella Rangel PanizPaula Baptista SanseverinoPaulo Dornelles PiconPietro Baptista de AzevedoMarta Haas CostaLavinia Schuler-FacciniMaria Teresa Vieira SanseverinoINTRODUCTION: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic effects of pregnancies exposed to the H1N1 virus during the Influenza A epidemic that occurred in the state of Rio Grande do Sul in 2009. METHODS: This is an uncontrolled prospective cohort study of pregnant women with suspected symptoms of Influenza A who were reported in the Information System for Notifiable Diseases-Influenza (SINAN-Influenza) during the epidemic of 2009 (database from the state of Rio Grande do Sul, Brazil). There were 589 cases of pregnant women with suspected infection. Among these, 243 were tested by PCR and included in the analysis. The main outcome measures were: maternal deaths, pregnancy outcome, stillbirths, premature births, low birth weight, congenital malformations, and odds ratios for H1N1+ and non-H1N1 pregnant women. RESULTS: There were one hundred and sixty-three (67%) confirmed cases of H1N1, 34 cases (14%) of seasonal Influenza A and 46 (19%) who were negative for Influenza A. There was no difference between the three groups in clinical parameters of the disease. There were 24 maternal deaths--18 of them had H1N1. There were 8 stillbirths--5 were children of H1N1 infected mothers. There were no differences in perinatal outcomes. CONCLUSIONS: The present data do not indicate an increase in teratogenic risk from exposure to the influenza A (H1N1) virus. These results will help to strengthen the data and clarify the health issues that arose after the pandemic.http://europepmc.org/articles/PMC3928255?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author André Anjos da Silva
Tani Maria Schilling Ranieri
Fernanda Duarte Torres
Fernanda Sales Luiz Vianna
Graziella Rangel Paniz
Paula Baptista Sanseverino
Paulo Dornelles Picon
Pietro Baptista de Azevedo
Marta Haas Costa
Lavinia Schuler-Faccini
Maria Teresa Vieira Sanseverino
spellingShingle André Anjos da Silva
Tani Maria Schilling Ranieri
Fernanda Duarte Torres
Fernanda Sales Luiz Vianna
Graziella Rangel Paniz
Paula Baptista Sanseverino
Paulo Dornelles Picon
Pietro Baptista de Azevedo
Marta Haas Costa
Lavinia Schuler-Faccini
Maria Teresa Vieira Sanseverino
Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
PLoS ONE
author_facet André Anjos da Silva
Tani Maria Schilling Ranieri
Fernanda Duarte Torres
Fernanda Sales Luiz Vianna
Graziella Rangel Paniz
Paula Baptista Sanseverino
Paulo Dornelles Picon
Pietro Baptista de Azevedo
Marta Haas Costa
Lavinia Schuler-Faccini
Maria Teresa Vieira Sanseverino
author_sort André Anjos da Silva
title Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
title_short Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
title_full Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
title_fullStr Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
title_full_unstemmed Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study.
title_sort impact on pregnancies in south brazil from the influenza a (h1n1) pandemic: cohort study.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description INTRODUCTION: The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population. Pregnant women are considered to be a group at risk of serious complications related to the H1N1 influenza virus. The aim of this study was to evaluate the outcomes and teratogenic effects of pregnancies exposed to the H1N1 virus during the Influenza A epidemic that occurred in the state of Rio Grande do Sul in 2009. METHODS: This is an uncontrolled prospective cohort study of pregnant women with suspected symptoms of Influenza A who were reported in the Information System for Notifiable Diseases-Influenza (SINAN-Influenza) during the epidemic of 2009 (database from the state of Rio Grande do Sul, Brazil). There were 589 cases of pregnant women with suspected infection. Among these, 243 were tested by PCR and included in the analysis. The main outcome measures were: maternal deaths, pregnancy outcome, stillbirths, premature births, low birth weight, congenital malformations, and odds ratios for H1N1+ and non-H1N1 pregnant women. RESULTS: There were one hundred and sixty-three (67%) confirmed cases of H1N1, 34 cases (14%) of seasonal Influenza A and 46 (19%) who were negative for Influenza A. There was no difference between the three groups in clinical parameters of the disease. There were 24 maternal deaths--18 of them had H1N1. There were 8 stillbirths--5 were children of H1N1 infected mothers. There were no differences in perinatal outcomes. CONCLUSIONS: The present data do not indicate an increase in teratogenic risk from exposure to the influenza A (H1N1) virus. These results will help to strengthen the data and clarify the health issues that arose after the pandemic.
url http://europepmc.org/articles/PMC3928255?pdf=render
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