Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma
Introduction: Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. Objectives: To assess the prognostic value...
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doaj-9d795ff2f08d4260b09263e80a308b9d2021-07-17T04:33:05ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942021-07-01874416421Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinomaMehmet Akif Abakay0Selçuk Güneş1Filiz Gülüstan2Health Science University Bakırköy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey; Corresponding author.Memorial Hizmet Hospital, Istanbul, TurkeyHealth Science University Bakırköy Dr Sadi Konuk Research and Training Hospital, Istanbul, TurkeyIntroduction: Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. Objectives: To assess the prognostic values of metastatic lymph node number, ipsilateral/contralateral harvested lymph nodes, and lymph node ratio in patients undergoing surgical treatment of laryngeal squamous cell carcinoma. Methods: Seventy-four patients diagnosed with laryngeal squamous cell carcinoma primarily managed surgically were included in this study. The patients’ pathological and survival data were obtained from their medical records. The effects of harvested lymph nodes and lymph node ratio on disease-free survival, disease-specific survival, and overall survival were analyzed. Results: Ipsilateral, contralateral, and bilateral evaluations of harvested lymph nodes showed no significant associations with prognosis. Lymph node ratio was significantly associated with overall survival when evaluated bilaterally. Metastatic lymph node number showed more suitable stratification than TNM classification. Conclusions: Metastatic lymph node number and bilateral lymph node ratio parameters should be taken into consideration to improve the prognostic capacity of TNM.http://www.sciencedirect.com/science/article/pii/S1808869420301427PrognosisSurvivalNeck dissectionMetastaseLymph node |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehmet Akif Abakay Selçuk Güneş Filiz Gülüstan |
spellingShingle |
Mehmet Akif Abakay Selçuk Güneş Filiz Gülüstan Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma Brazilian Journal of Otorhinolaryngology Prognosis Survival Neck dissection Metastase Lymph node |
author_facet |
Mehmet Akif Abakay Selçuk Güneş Filiz Gülüstan |
author_sort |
Mehmet Akif Abakay |
title |
Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
title_short |
Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
title_full |
Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
title_fullStr |
Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
title_full_unstemmed |
Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
title_sort |
prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma |
publisher |
Elsevier |
series |
Brazilian Journal of Otorhinolaryngology |
issn |
1808-8694 |
publishDate |
2021-07-01 |
description |
Introduction: Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. Objectives: To assess the prognostic values of metastatic lymph node number, ipsilateral/contralateral harvested lymph nodes, and lymph node ratio in patients undergoing surgical treatment of laryngeal squamous cell carcinoma. Methods: Seventy-four patients diagnosed with laryngeal squamous cell carcinoma primarily managed surgically were included in this study. The patients’ pathological and survival data were obtained from their medical records. The effects of harvested lymph nodes and lymph node ratio on disease-free survival, disease-specific survival, and overall survival were analyzed. Results: Ipsilateral, contralateral, and bilateral evaluations of harvested lymph nodes showed no significant associations with prognosis. Lymph node ratio was significantly associated with overall survival when evaluated bilaterally. Metastatic lymph node number showed more suitable stratification than TNM classification. Conclusions: Metastatic lymph node number and bilateral lymph node ratio parameters should be taken into consideration to improve the prognostic capacity of TNM. |
topic |
Prognosis Survival Neck dissection Metastase Lymph node |
url |
http://www.sciencedirect.com/science/article/pii/S1808869420301427 |
work_keys_str_mv |
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