High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data
A number of biomarkers have been identified for various cancers. However, biomarkers associated with glioma remain largely to be explored. In the current study, we investigated the relationship between the expression and prognostic value of the HIST1H2BK gene in glioma. Sequential data filtering (su...
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doaj-9d8052afd3f946f382a1082e4f603ca12020-11-25T02:16:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00627519166High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA DataWeidong Liu0Zhentao Xu1Jie Zhou2Shuang Xing3Zhiqiang Li4Xu Gao5Shiyu Feng6Yilei Xiao7Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, ChinaDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, ChinaDepartment of Nursing, Liaocheng Vocational and Technical College, Liaocheng, ChinaDepartment of Nursing, Liaocheng Vocational and Technical College, Liaocheng, ChinaDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurosurgery, General Hospital of Northern Theater Command (General Hospital of Shenyang Military), Shenyang, ChinaDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, ChinaA number of biomarkers have been identified for various cancers. However, biomarkers associated with glioma remain largely to be explored. In the current study, we investigated the relationship between the expression and prognostic value of the HIST1H2BK gene in glioma. Sequential data filtering (survival analysis, independent prognostic analysis, ROC curve analysis, and clinical correlation analysis) was performed, which resulted in identification of the association between the HIST1H2BK gene and glioma. Then, the HIST1H2BK gene was analyzed using bioinformatics (Kaplan–Meier survival analysis, univariate Cox analysis, multivariate Cox analysis, and ROC curve analysis). The results showed that low expression of HIST1H2BK was associated with better prognosis, and high expression of HIST1H2BK was associated with poor prognosis. In addition, HIST1H2BK was an independent prognostic indicator for patients with glioma. We also evaluated the association between HIST1H2BK and clinical characteristics. Furthermore, gene set enrichment analysis (GSEA) and analysis of immune infiltration were performed. The results showed that HIST1H2BK was associated with intensity of immune infiltration in glioma. Finally, co-expression analysis was performed. The results showed that HIST1H2BK was positively correlated with HIST1H2AG, HIST2H2AA4, HIST1H2BJ, HIST2H2BE, and HIST1H2AC, and negatively correlated with PDZD4, CRY2, GABBR1, rp5-1119a7.17, and KCNJ11. This study showed that upregulation of HIST1H2BK in low-grade glioma (LGG) tissue was an indicator of poor prognosis. Moreover, this study demonstrated that HIST1H2BK may be a promising biomarker for the treatment of LGG.https://www.frontiersin.org/article/10.3389/fonc.2020.00627/fullHIST1H2BKgliomaprognosisCGGATCGA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weidong Liu Zhentao Xu Jie Zhou Shuang Xing Zhiqiang Li Xu Gao Shiyu Feng Yilei Xiao |
spellingShingle |
Weidong Liu Zhentao Xu Jie Zhou Shuang Xing Zhiqiang Li Xu Gao Shiyu Feng Yilei Xiao High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data Frontiers in Oncology HIST1H2BK glioma prognosis CGGA TCGA |
author_facet |
Weidong Liu Zhentao Xu Jie Zhou Shuang Xing Zhiqiang Li Xu Gao Shiyu Feng Yilei Xiao |
author_sort |
Weidong Liu |
title |
High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data |
title_short |
High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data |
title_full |
High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data |
title_fullStr |
High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data |
title_full_unstemmed |
High Levels of HIST1H2BK in Low-Grade Glioma Predicts Poor Prognosis: A Study Using CGGA and TCGA Data |
title_sort |
high levels of hist1h2bk in low-grade glioma predicts poor prognosis: a study using cgga and tcga data |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-05-01 |
description |
A number of biomarkers have been identified for various cancers. However, biomarkers associated with glioma remain largely to be explored. In the current study, we investigated the relationship between the expression and prognostic value of the HIST1H2BK gene in glioma. Sequential data filtering (survival analysis, independent prognostic analysis, ROC curve analysis, and clinical correlation analysis) was performed, which resulted in identification of the association between the HIST1H2BK gene and glioma. Then, the HIST1H2BK gene was analyzed using bioinformatics (Kaplan–Meier survival analysis, univariate Cox analysis, multivariate Cox analysis, and ROC curve analysis). The results showed that low expression of HIST1H2BK was associated with better prognosis, and high expression of HIST1H2BK was associated with poor prognosis. In addition, HIST1H2BK was an independent prognostic indicator for patients with glioma. We also evaluated the association between HIST1H2BK and clinical characteristics. Furthermore, gene set enrichment analysis (GSEA) and analysis of immune infiltration were performed. The results showed that HIST1H2BK was associated with intensity of immune infiltration in glioma. Finally, co-expression analysis was performed. The results showed that HIST1H2BK was positively correlated with HIST1H2AG, HIST2H2AA4, HIST1H2BJ, HIST2H2BE, and HIST1H2AC, and negatively correlated with PDZD4, CRY2, GABBR1, rp5-1119a7.17, and KCNJ11. This study showed that upregulation of HIST1H2BK in low-grade glioma (LGG) tissue was an indicator of poor prognosis. Moreover, this study demonstrated that HIST1H2BK may be a promising biomarker for the treatment of LGG. |
topic |
HIST1H2BK glioma prognosis CGGA TCGA |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00627/full |
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