The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders.

Deficits in sensorimotor gating measured by prepulse inhibition (PPI) of the startle have been known as characteristics of patients with schizophrenia and related neuropsychiatric disorders. PPI disruption is thought to rely on the activity of the mesocorticolimbic dopaminergic system and is inhibit...

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Bibliographic Details
Main Authors: Shinjae Chung, Michel M M Verheij, Peter Hesseling, Ruben W M van Vugt, Mahalah Buell, James D Belluzzi, Mark A Geyer, Gerard J M Martens, Olivier Civelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3139593?pdf=render