Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacter...

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Main Authors: Zhaopin Gou, Dequn Sun, Man Pan, Xiaoli Wang, Min Luo, Jie Wu, Li Sun
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Molecules
Subjects:
benzophenone derivatives
bioactivity
phytopathogenic fungi
vibrio
Online Access:http://www.mdpi.com/1420-3049/16/11/9739/
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spelling doaj-9d889d547ddc4a899e6600d7931b1bb22020-11-24T23:13:32ZengMDPI AGMolecules1420-30492011-11-0116119739975410.3390/molecules16119739Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial ActivitiesZhaopin GouDequn SunMan PanXiaoli WangMin LuoJie WuLi SunA series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.http://www.mdpi.com/1420-3049/16/11/9739/benzophenone derivativesbioactivityphytopathogenic fungivibrio
collection DOAJ
language English
format Article
sources DOAJ
author Zhaopin Gou
Dequn Sun
Man Pan
Xiaoli Wang
Min Luo
Jie Wu
Li Sun
spellingShingle Zhaopin Gou
Dequn Sun
Man Pan
Xiaoli Wang
Min Luo
Jie Wu
Li Sun
Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
Molecules
benzophenone derivatives
bioactivity
phytopathogenic fungi
vibrio
author_facet Zhaopin Gou
Dequn Sun
Man Pan
Xiaoli Wang
Min Luo
Jie Wu
Li Sun
author_sort Zhaopin Gou
title Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_short Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_full Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_fullStr Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_full_unstemmed Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities
title_sort diversity oriented design of various benzophenone derivatives and their in vitro antifungal and antibacterial activities
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2011-11-01
description A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.
topic benzophenone derivatives
bioactivity
phytopathogenic fungi
vibrio
url http://www.mdpi.com/1420-3049/16/11/9739/
work_keys_str_mv AT zhaopingou diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT dequnsun diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT manpan diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT xiaoliwang diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT minluo diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT jiewu diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
AT lisun diversityorienteddesignofvariousbenzophenonederivativesandtheirinvitroantifungalandantibacterialactivities
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