Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex.
Objective. To determine the clinical characteristics of NAFLD in asymptomatic obese women.Methods. A total of 457 asymptomatic obese women were enrolled in a cross-sectional study and allocated into groups with and without NAFLD. Irrespective of ALT levels, diagnosis of NAFLD was established by ultr...
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doaj-9d8e49b2704b4fd78d730a0ec931e17c2021-06-09T05:55:30ZengElsevierAnnals of Hepatology1665-26812010-04-0192144149Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex.Heriberto Rodriguez-Hernandez0Miriam Cervantes-Huerta1Jose Luis Gonzalez2María Dolores Marquez-Ramirez3Martha Rodriguez-Moran4Fernando Guerrero-Romero, MD, PhD5Biomedical Research Unit, Mexican Social Security Institute; Research Group on Diabetes and Chronic Illnesses, Durango, Mexico; Faculty of Medicine, Juarez University of Durango StateBiomedical Research Unit, Mexican Social Security InstitutePathology Department, General Hospital of the Mexican Social Security Institute Durango, Dgo. MéxicoRadiology Department, General Hospital of the Mexican Social Security Institute Durango, Dgo. MéxicoBiomedical Research Unit, Mexican Social Security Institute; Research Group on Diabetes and Chronic Illnesses, Durango, MexicoBiomedical Research Unit, Mexican Social Security Institute; Research Group on Diabetes and Chronic Illnesses, Durango, Mexico; Correspondence and reprint request:Objective. To determine the clinical characteristics of NAFLD in asymptomatic obese women.Methods. A total of 457 asymptomatic obese women were enrolled in a cross-sectional study and allocated into groups with and without NAFLD. Irrespective of ALT levels, diagnosis of NAFLD was established by ultrasonographic findings; irrespective of fibrosis, NASH was defined by hepatic histological changes.Results. One hundred ninety five (42.7%) women had elevated ALT levels. Diagnosis of NAFLD was established in 228 (49.9%) women; among women with NAFLD, 34 (14.9%) have ALT levels within the normal range. On the other hand, based on the healthy range for ALT levels (19 UI/L), 336 (73.5%) women had elevated ALT, but only 2 (0.9%) women with NAFLD exhibited ALT levels within normal healthy values. Furthermore, 93 (41%) women who had AST/ALT levels 3 1 underwent liver biopsy; of these, 90 (96.8%) had diagnosis of NASH and 3 (3.2%) of hepatic cirrhosis. Women with NAFLD were more obese and have higher fasting plasma glucose, triglycerides, ALT, and AST levels than obese women without NAFLD. Seventy six (16.6%) women had diagnosis of diabetes; of these 47 (61.8) in the NAFLD group.Conclusions. Results of this study support the statement that women with NAFLD have an adverse metabolic profile. Furthermore, our results show that hyperglycemia, hypertriglyceridemia and markers of liver injury such as AST/ALT ≥ 1 may be useful for early recognition of NAFLD.http://www.sciencedirect.com/science/article/pii/S1665268119316527ObesitySteatosisNAFLDDiabetesNASH |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heriberto Rodriguez-Hernandez Miriam Cervantes-Huerta Jose Luis Gonzalez María Dolores Marquez-Ramirez Martha Rodriguez-Moran Fernando Guerrero-Romero, MD, PhD |
spellingShingle |
Heriberto Rodriguez-Hernandez Miriam Cervantes-Huerta Jose Luis Gonzalez María Dolores Marquez-Ramirez Martha Rodriguez-Moran Fernando Guerrero-Romero, MD, PhD Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. Annals of Hepatology Obesity Steatosis NAFLD Diabetes NASH |
author_facet |
Heriberto Rodriguez-Hernandez Miriam Cervantes-Huerta Jose Luis Gonzalez María Dolores Marquez-Ramirez Martha Rodriguez-Moran Fernando Guerrero-Romero, MD, PhD |
author_sort |
Heriberto Rodriguez-Hernandez |
title |
Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. |
title_short |
Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. |
title_full |
Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. |
title_fullStr |
Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. |
title_full_unstemmed |
Nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)The work was originated in the Biomedical Research Unit of The Mexican Social Security Institute at Durango, Mex. |
title_sort |
nonalcoholic fatty liver disease in asymptomatic obese women(a)(a)the work was originated in the biomedical research unit of the mexican social security institute at durango, mex. |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2010-04-01 |
description |
Objective. To determine the clinical characteristics of NAFLD in asymptomatic obese women.Methods. A total of 457 asymptomatic obese women were enrolled in a cross-sectional study and allocated into groups with and without NAFLD. Irrespective of ALT levels, diagnosis of NAFLD was established by ultrasonographic findings; irrespective of fibrosis, NASH was defined by hepatic histological changes.Results. One hundred ninety five (42.7%) women had elevated ALT levels. Diagnosis of NAFLD was established in 228 (49.9%) women; among women with NAFLD, 34 (14.9%) have ALT levels within the normal range. On the other hand, based on the healthy range for ALT levels (19 UI/L), 336 (73.5%) women had elevated ALT, but only 2 (0.9%) women with NAFLD exhibited ALT levels within normal healthy values. Furthermore, 93 (41%) women who had AST/ALT levels 3 1 underwent liver biopsy; of these, 90 (96.8%) had diagnosis of NASH and 3 (3.2%) of hepatic cirrhosis. Women with NAFLD were more obese and have higher fasting plasma glucose, triglycerides, ALT, and AST levels than obese women without NAFLD. Seventy six (16.6%) women had diagnosis of diabetes; of these 47 (61.8) in the NAFLD group.Conclusions. Results of this study support the statement that women with NAFLD have an adverse metabolic profile. Furthermore, our results show that hyperglycemia, hypertriglyceridemia and markers of liver injury such as AST/ALT ≥ 1 may be useful for early recognition of NAFLD. |
topic |
Obesity Steatosis NAFLD Diabetes NASH |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119316527 |
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