The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet
Background: The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Methods: Sixty rats were divided into five groups in descending order of body weight. Except f...
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doaj-9daa36d3a6f549d0800dd63384856f442020-11-24T20:59:42ZengElsevierJournal of Ginseng Research1226-84532017-04-0141212012610.1016/j.jgr.2016.01.004The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat dietMin Hee Kim0Jongsung Lee1Sehyun Jung2Joo Wan Kim3Jae-Ho Shin4Hae-Jeung Lee5Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi-do, KoreaDepartment of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Gyeonggi-do, KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Gyeonggi-do, KoreaNatural Product Research Center, Aribio Co. Ltd., Gyoenggi-do, KoreaDepartment of Biomedical Laboratory Science, College of Health Science, Eulji University, Gyeonggi-do, KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Gyeonggi-do, KoreaBackground: The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Methods: Sixty rats were divided into five groups in descending order of body weight. Except for the control group, the other four groups were fed a HFD containing 45% kcal from fat for 11 wk without GBx. GBx groups were then additionally treated by gastric gavage with GBx dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, or 150 (GBx 150) mg/kg body weight for 6 wk along with the HFD. To investigate the effects of GBx on rats fed a HFD, biochemical metabolite, blood coagulation assay, and histological analysis were performed. Results: In the experiments to measure the serum levels of leptin and apolipoprotein B/A, GBx treatment attenuated the HFD-induced increases in these metabolites (p < 0.05). Adiponectin and apolipoprotein E levels in GBx-treated groups were significantly higher than the HFD group. Prothrombin time and activated partial thromboplastin time were increased in all GBx-treated groups. In the GBx-treated groups, the serum levels of thromboxane A2 and serotonin were decreased and concentrations of serum fibrinogen degradation products were increased (p < 0.05). Moreover, histomorphometric dyslipidemia-related atherosclerotic changes were significantly improved by treatment with GBx. Conclusion: These results suggest the possibility that GBx can ameliorate blood flow by decreasing intima-media thickness via the regulation of blood coagulation factors related to lipid metabolites in rats fed a HFD.http://www.sciencedirect.com/science/article/pii/S1226845316000063blood coagulationblood flowginseng berryhigh-fat dietlipid metabolite |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Hee Kim Jongsung Lee Sehyun Jung Joo Wan Kim Jae-Ho Shin Hae-Jeung Lee |
spellingShingle |
Min Hee Kim Jongsung Lee Sehyun Jung Joo Wan Kim Jae-Ho Shin Hae-Jeung Lee The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet Journal of Ginseng Research blood coagulation blood flow ginseng berry high-fat diet lipid metabolite |
author_facet |
Min Hee Kim Jongsung Lee Sehyun Jung Joo Wan Kim Jae-Ho Shin Hae-Jeung Lee |
author_sort |
Min Hee Kim |
title |
The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
title_short |
The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
title_full |
The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
title_fullStr |
The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
title_full_unstemmed |
The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
title_sort |
involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet |
publisher |
Elsevier |
series |
Journal of Ginseng Research |
issn |
1226-8453 |
publishDate |
2017-04-01 |
description |
Background: The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD).
Methods: Sixty rats were divided into five groups in descending order of body weight. Except for the control group, the other four groups were fed a HFD containing 45% kcal from fat for 11 wk without GBx. GBx groups were then additionally treated by gastric gavage with GBx dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, or 150 (GBx 150) mg/kg body weight for 6 wk along with the HFD. To investigate the effects of GBx on rats fed a HFD, biochemical metabolite, blood coagulation assay, and histological analysis were performed.
Results: In the experiments to measure the serum levels of leptin and apolipoprotein B/A, GBx treatment attenuated the HFD-induced increases in these metabolites (p < 0.05). Adiponectin and apolipoprotein E levels in GBx-treated groups were significantly higher than the HFD group. Prothrombin time and activated partial thromboplastin time were increased in all GBx-treated groups. In the GBx-treated groups, the serum levels of thromboxane A2 and serotonin were decreased and concentrations of serum fibrinogen degradation products were increased (p < 0.05). Moreover, histomorphometric dyslipidemia-related atherosclerotic changes were significantly improved by treatment with GBx.
Conclusion: These results suggest the possibility that GBx can ameliorate blood flow by decreasing intima-media thickness via the regulation of blood coagulation factors related to lipid metabolites in rats fed a HFD. |
topic |
blood coagulation blood flow ginseng berry high-fat diet lipid metabolite |
url |
http://www.sciencedirect.com/science/article/pii/S1226845316000063 |
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