A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder
Background: Major depressive disorder (MDD) is a mental disorder characterized by episodes of depressed mood, loss of interest or pleasure, feeling of guilt or low self-esteem, loss of energy, altered sleep patterns and difficulty in concentration. Objective: This study was carried out to compare...
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doaj-9db2670fd3164ef786881e6d39871b442020-11-25T03:43:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-06-0196VC05VC0810.7860/JCDR/2015/12371.6092A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive DisorderRavi Babu. Komaram0Srikrishna. Nukala1Jayasree. Palla2Lakshmana Rao. Nambaru3Satyanarayana Murthy. Kasturi4Associate Professor, Department of Pharmacology, GSL Medical college & General Hospital, Rajahmundry, Andhra Pradesh, India.Associate Professor, Department of Psychiatry, GSL Medical college & General Hospital, Rajahmundry, Andhra Pradesh, India.Postgraduate Student, Department of Community Medicine, GSL Medical college & General Hospital, Rajahmundry, Andhra Pradesh, India.Assistant Professor in statistics, Department of Community Medicine, RIMS, Ongole, Andhra Pradesh, India.Professor & HOD, Department of Pharmacology, GSL Medical college & General Hospital, Rajahmundry, Andhra Pradesh, India.Background: Major depressive disorder (MDD) is a mental disorder characterized by episodes of depressed mood, loss of interest or pleasure, feeling of guilt or low self-esteem, loss of energy, altered sleep patterns and difficulty in concentration. Objective: This study was carried out to compare the efficacy and safety of Agomelatine with Escitalopram in the treatment of major depressive disorder. Design and Setting: This is a prospective study conducted at Outpatient Department of Psychiatry, GSL Medical College & General hospital, Rajahmundry, India. Materials and Methods: Patients with newly diagnosed major depressive disorder (DSM-IV-TR) with minimum score of 20 in Hamilton depression rating scale were randomly assigned Agomelatine (25-50 mg/day) or Escitalopram (10-20 mg/day) for a period of 8 weeks. The main efficacy outcome considered was the mean change of HAM-D17 score from baseline to end of therapy. Secondary outcome measures were Clinical Global Impressions– improvement (CGI) and severity (CGI-S) rating scales. Statistical Analysis: Student t-test was used for comparing the groups and chi-square test was used for assessing the qualitative variables. For all statistical analysis p<0.05 was considered statistically significant. Results: The drugs under study effectively reduced depressive symptoms at all the time points. The percentage of responders at 8weeks (last post baseline value) was 65.38% with Agomelatine and 57.40% with Escitalopram. The difference between the drugs was statistically not significant in all evaluations (p>0.05). The mean CGI-S and CGI-I scores were decreased in both the groups (p<0.05) and there was no statistically significant difference between the groups at any assessment during the study period. Both the treatment groups showed favourable safety profile. Conclusion: The study results supported that Agomelatine is therapeutically similar to Escitalopram in terms of antidepressant effect.https://jcdr.net/articles/PDF/6092/12371_CE(RA1)_F(T)_PF1(PAK)_PFA(P)_PF2(PAG).pdfantidepressantsdepressionmelatonergic receptors5-ht2c receptors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ravi Babu. Komaram Srikrishna. Nukala Jayasree. Palla Lakshmana Rao. Nambaru Satyanarayana Murthy. Kasturi |
spellingShingle |
Ravi Babu. Komaram Srikrishna. Nukala Jayasree. Palla Lakshmana Rao. Nambaru Satyanarayana Murthy. Kasturi A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder Journal of Clinical and Diagnostic Research antidepressants depression melatonergic receptors 5-ht2c receptors |
author_facet |
Ravi Babu. Komaram Srikrishna. Nukala Jayasree. Palla Lakshmana Rao. Nambaru Satyanarayana Murthy. Kasturi |
author_sort |
Ravi Babu. Komaram |
title |
A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder |
title_short |
A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder |
title_full |
A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder |
title_fullStr |
A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder |
title_full_unstemmed |
A Comparative Study of Efficacy and Safety of Agomelatine and Escitalopram in Major Depressive Disorder |
title_sort |
comparative study of efficacy and safety of agomelatine and escitalopram in major depressive disorder |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2015-06-01 |
description |
Background: Major depressive disorder (MDD) is a mental disorder characterized by episodes of depressed mood, loss of interest
or pleasure, feeling of guilt or low self-esteem, loss of energy, altered
sleep patterns and difficulty in concentration.
Objective: This study was carried out to compare the efficacy
and safety of Agomelatine with Escitalopram in the treatment of
major depressive disorder.
Design and Setting: This is a prospective study conducted at
Outpatient Department of Psychiatry, GSL Medical College &
General hospital, Rajahmundry, India.
Materials and Methods: Patients with newly diagnosed major
depressive disorder (DSM-IV-TR) with minimum score of 20
in Hamilton depression rating scale were randomly assigned
Agomelatine (25-50 mg/day) or Escitalopram (10-20 mg/day) for a
period of 8 weeks. The main efficacy outcome considered was the
mean change of HAM-D17 score from baseline to end of therapy.
Secondary outcome measures were Clinical Global Impressions–
improvement (CGI) and severity (CGI-S) rating scales.
Statistical Analysis: Student t-test was used for comparing the
groups and chi-square test was used for assessing the qualitative
variables. For all statistical analysis p<0.05 was considered
statistically significant.
Results: The drugs under study effectively reduced depressive
symptoms at all the time points. The percentage of responders at
8weeks (last post baseline value) was 65.38% with Agomelatine
and 57.40% with Escitalopram. The difference between the
drugs was statistically not significant in all evaluations (p>0.05).
The mean CGI-S and CGI-I scores were decreased in both the
groups (p<0.05) and there was no statistically significant difference
between the groups at any assessment during the study period.
Both the treatment groups showed favourable safety profile.
Conclusion: The study results supported that Agomelatine is therapeutically similar to Escitalopram in terms of antidepressant effect. |
topic |
antidepressants depression melatonergic receptors 5-ht2c receptors |
url |
https://jcdr.net/articles/PDF/6092/12371_CE(RA1)_F(T)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
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