Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins

Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins

Herein, we report the synthesis of an interesting graphene quantum material called “graphene quantum pins (GQPs)”. Morphological analysis revealed the interesting pin shape (width: ~10 nm, length: 50–100 nm) and spectral analysis elucidated the surface functional groups, structural features, energy...

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Main Authors: Seong-Beom Jeon, Monica Samal, Saravanan Govindaraju, Rupasree Ragini Das, Kyusik Yun
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Nanomaterials
Subjects:
graphene quantum pins
photoluminescence
cytotoxicity
cellular response
cellular distribution
Online Access:https://www.mdpi.com/2079-4991/10/12/2550
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spelling doaj-9db63cc905db4dee8634baecf29152e42020-12-19T00:03:38ZengMDPI AGNanomaterials2079-49912020-12-01102550255010.3390/nano10122550Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum PinsSeong-Beom Jeon0Monica Samal1Saravanan Govindaraju2Rupasree Ragini Das3Kyusik Yun4Department of Bionanotechnology, Gachon University, Seongnam 13120, KoreaDepartment of Material Science and Engineering, North Carolina State University, Raleigh, NC 27695, USADepartment of Bionanotechnology, Gachon University, Seongnam 13120, KoreaDepartment of Bionanotechnology, Gachon University, Seongnam 13120, KoreaDepartment of Bionanotechnology, Gachon University, Seongnam 13120, KoreaHerein, we report the synthesis of an interesting graphene quantum material called “graphene quantum pins (GQPs)”. Morphological analysis revealed the interesting pin shape (width: ~10 nm, length: 50–100 nm) and spectral analysis elucidated the surface functional groups, structural features, energy levels, and photoluminescence properties (blue emission under 365 nm). The difference between the GQPs and graphene quantum dos (GQDs) isolated from the same reaction mixture as regards to their morphological, structural, and photoluminescence properties are also discussed along with the suggestion of a growth mechanism. Cytotoxicity and cellular responses including changes in biophysical and biomechanical properties were evaluated for possible biomedical applications of GQPs. The studies demonstrated the biocompatibility of GQPs even at a high concentration of 512 μg/mL. Our results suggest GQPs can be used as a potential bio-imaging agent with desired photoluminescence property and low cytotoxicity.https://www.mdpi.com/2079-4991/10/12/2550graphene quantum pinsphotoluminescencecytotoxicitycellular responsecellular distribution
collection DOAJ
language English
format Article
sources DOAJ
author Seong-Beom Jeon
Monica Samal
Saravanan Govindaraju
Rupasree Ragini Das
Kyusik Yun
spellingShingle Seong-Beom Jeon
Monica Samal
Saravanan Govindaraju
Rupasree Ragini Das
Kyusik Yun
Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
Nanomaterials
graphene quantum pins
photoluminescence
cytotoxicity
cellular response
cellular distribution
author_facet Seong-Beom Jeon
Monica Samal
Saravanan Govindaraju
Rupasree Ragini Das
Kyusik Yun
author_sort Seong-Beom Jeon
title Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
title_short Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
title_full Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
title_fullStr Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
title_full_unstemmed Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins
title_sort cytotoxicity and bioimaging study for nhdf and hela cell lines by using graphene quantum pins
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2020-12-01
description Herein, we report the synthesis of an interesting graphene quantum material called “graphene quantum pins (GQPs)”. Morphological analysis revealed the interesting pin shape (width: ~10 nm, length: 50–100 nm) and spectral analysis elucidated the surface functional groups, structural features, energy levels, and photoluminescence properties (blue emission under 365 nm). The difference between the GQPs and graphene quantum dos (GQDs) isolated from the same reaction mixture as regards to their morphological, structural, and photoluminescence properties are also discussed along with the suggestion of a growth mechanism. Cytotoxicity and cellular responses including changes in biophysical and biomechanical properties were evaluated for possible biomedical applications of GQPs. The studies demonstrated the biocompatibility of GQPs even at a high concentration of 512 μg/mL. Our results suggest GQPs can be used as a potential bio-imaging agent with desired photoluminescence property and low cytotoxicity.
topic graphene quantum pins
photoluminescence
cytotoxicity
cellular response
cellular distribution
url https://www.mdpi.com/2079-4991/10/12/2550
work_keys_str_mv AT seongbeomjeon cytotoxicityandbioimagingstudyfornhdfandhelacelllinesbyusinggraphenequantumpins
AT monicasamal cytotoxicityandbioimagingstudyfornhdfandhelacelllinesbyusinggraphenequantumpins
AT saravanangovindaraju cytotoxicityandbioimagingstudyfornhdfandhelacelllinesbyusinggraphenequantumpins
AT rupasreeraginidas cytotoxicityandbioimagingstudyfornhdfandhelacelllinesbyusinggraphenequantumpins
AT kyusikyun cytotoxicityandbioimagingstudyfornhdfandhelacelllinesbyusinggraphenequantumpins
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