Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year
<p>Abstract</p> <p>Background</p> <p>The new generation nebuliser PARI eFlow<sup>® </sup>rapid allows a highly efficient aerosol delivery at reduced inhalation time. However, lung function data during long-term use of this device are not available until now....
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doaj-9db965af024b4ac98a54f9e583eb87cc2020-11-24T21:52:07ZengBMCEuropean Journal of Medical Research2047-783X2011-02-011626310.1186/2047-783X-16-2-63Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one yearNaehrig SLang SSchiffl HHuber RMFischer R<p>Abstract</p> <p>Background</p> <p>The new generation nebuliser PARI eFlow<sup>® </sup>rapid allows a highly efficient aerosol delivery at reduced inhalation time. However, lung function data during long-term use of this device are not available until now.</p> <p>Methods</p> <p>70 clinically stable adult cystic fibrosis patients participated in this observation study. Lung function tests were performed prospectively 12 weeks after and again 9 to 12 months after switching the inhalation device from a conventional jet nebulizer to the PARI eFlow<sup>® </sup>rapid. Lung function data were collected retrospectively from the visits 1 year as well as 12 weeks prior to the switch-over. Lung function data for all time points were only available for 59 patients. Treatment time and patient's satification were recorded for both conventional and new nebuliser in all 70 patients.</p> <p>Results</p> <p>After 1 year of inhalation with eFlow<sup>® </sup>rapid, the mean change in FEV1% was -- 1.4% (n = 59 patients). The decrease in FEV1 was smaller than the change in FEV1 after 1 year of inhalation with the conventional jet nebuliser (control period, -3.1%), although this difference was not statistically significant. The same effect was seen in MEF25[%] '(-2.6% with conventional nebuliser compared to --1.6% after eFlow<sup>® </sup>rapid). Concerning the FVC, there was a greater improvement after 1 year of inhalation with the eFlow<sup>® </sup>rapid than with the jet nebuliser (+ 2.9% vs. +1.1%). For PEF%, there was an increase during the control period, whereas after inhalation with eFlow<sup>® </sup>rapid there was a decrease (+1.1% vs. --2.9%). All changes were not significantly different. The eFlow<sup>® </sup>rapid reduced total daily inhalation time by two-thirds (conventional nebuliser: 31.1 min/day; eFlow<sup>® </sup>rapid: 10.2 min/day, n = 70 patients)</p> <p>Conclusion</p> <p>Inhalation with the new nebuliser eFlow rapid does not alter FEV1, FVC or PEF significantly after 1 year of inhalation. The treatment time could be reduced significantly by the eFlow<sup>® </sup>rapid.</p> http://www.eurjmedres.com/content/16/2/63Cystic fibrosisinhalationnebulisereFlow<sup>® </sup>rapidinhalation timelung function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naehrig S Lang S Schiffl H Huber RM Fischer R |
spellingShingle |
Naehrig S Lang S Schiffl H Huber RM Fischer R Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year European Journal of Medical Research Cystic fibrosis inhalation nebuliser eFlow<sup>® </sup>rapid inhalation time lung function |
author_facet |
Naehrig S Lang S Schiffl H Huber RM Fischer R |
author_sort |
Naehrig S |
title |
Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year |
title_short |
Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year |
title_full |
Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year |
title_fullStr |
Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year |
title_full_unstemmed |
Lung function in adult patients with cystic fibrosis after using the eFlow<sup>® </sup>rapid for one year |
title_sort |
lung function in adult patients with cystic fibrosis after using the eflow<sup>® </sup>rapid for one year |
publisher |
BMC |
series |
European Journal of Medical Research |
issn |
2047-783X |
publishDate |
2011-02-01 |
description |
<p>Abstract</p> <p>Background</p> <p>The new generation nebuliser PARI eFlow<sup>® </sup>rapid allows a highly efficient aerosol delivery at reduced inhalation time. However, lung function data during long-term use of this device are not available until now.</p> <p>Methods</p> <p>70 clinically stable adult cystic fibrosis patients participated in this observation study. Lung function tests were performed prospectively 12 weeks after and again 9 to 12 months after switching the inhalation device from a conventional jet nebulizer to the PARI eFlow<sup>® </sup>rapid. Lung function data were collected retrospectively from the visits 1 year as well as 12 weeks prior to the switch-over. Lung function data for all time points were only available for 59 patients. Treatment time and patient's satification were recorded for both conventional and new nebuliser in all 70 patients.</p> <p>Results</p> <p>After 1 year of inhalation with eFlow<sup>® </sup>rapid, the mean change in FEV1% was -- 1.4% (n = 59 patients). The decrease in FEV1 was smaller than the change in FEV1 after 1 year of inhalation with the conventional jet nebuliser (control period, -3.1%), although this difference was not statistically significant. The same effect was seen in MEF25[%] '(-2.6% with conventional nebuliser compared to --1.6% after eFlow<sup>® </sup>rapid). Concerning the FVC, there was a greater improvement after 1 year of inhalation with the eFlow<sup>® </sup>rapid than with the jet nebuliser (+ 2.9% vs. +1.1%). For PEF%, there was an increase during the control period, whereas after inhalation with eFlow<sup>® </sup>rapid there was a decrease (+1.1% vs. --2.9%). All changes were not significantly different. The eFlow<sup>® </sup>rapid reduced total daily inhalation time by two-thirds (conventional nebuliser: 31.1 min/day; eFlow<sup>® </sup>rapid: 10.2 min/day, n = 70 patients)</p> <p>Conclusion</p> <p>Inhalation with the new nebuliser eFlow rapid does not alter FEV1, FVC or PEF significantly after 1 year of inhalation. The treatment time could be reduced significantly by the eFlow<sup>® </sup>rapid.</p> |
topic |
Cystic fibrosis inhalation nebuliser eFlow<sup>® </sup>rapid inhalation time lung function |
url |
http://www.eurjmedres.com/content/16/2/63 |
work_keys_str_mv |
AT naehrigs lungfunctioninadultpatientswithcysticfibrosisafterusingtheeflowsupsuprapidforoneyear AT langs lungfunctioninadultpatientswithcysticfibrosisafterusingtheeflowsupsuprapidforoneyear AT schifflh lungfunctioninadultpatientswithcysticfibrosisafterusingtheeflowsupsuprapidforoneyear AT huberrm lungfunctioninadultpatientswithcysticfibrosisafterusingtheeflowsupsuprapidforoneyear AT fischerr lungfunctioninadultpatientswithcysticfibrosisafterusingtheeflowsupsuprapidforoneyear |
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