Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh
Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total o...
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doaj-9dc8c09540e74bba8acef7ffc89d387f2021-04-21T23:04:58ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-04-016585810.3390/tropicalmed6020058Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in BangladeshSnigdha Rahman Titir0Shyamal Kumar Paul1Salma Ahmed2Nazia Haque3Syeda Anjuman Nasreen4Khondoker Shoaib Hossain5Fahim Uddin Ahmad6Sultana Shabnam Nila7Jobyda Khanam8Neaz Nowsher9Abu Mohammod Mayeenuddin Al Amin10Amdad Ullah Khan11Meiji Soe Aung12Nobumichi Kobayashi13Department of Microbiology, Mymensingh Medical College, Mymensingh 2200, BangladeshNetrokona Medical College, Netrokona 2400, BangladeshDepartment of Microbiology, Mymensingh Medical College, Mymensingh 2200, BangladeshSheikh Hasina Medical College and Hospital, Jamalpur 1900, BangladeshDepartment of Microbiology, Mymensingh Medical College, Mymensingh 2200, BangladeshDepartment of Endocrinology, BIRDEM Academy, Dhaka 2302, BangladeshDepartment of Microbiology, TMSS Medical College, Bogura 5800, BangladeshDepartment of Microbiology, Mymensingh Medical College, Mymensingh 2200, BangladeshDepartment of Microbiology, Mymensingh Medical College, Mymensingh 2200, BangladeshDepartment of Pathology, Khulna Medical College, Khulna 9100, BangladeshDepartment of Microbiology, Gazi Medical College, Khulna 9000, BangladeshDepartment of Medicine, Mymensingh Medical College, Mymensingh 2200, BangladeshDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, JapanDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, JapanBangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total of 179 blood samples were collected from patients in 10 districts (seven divisions) covering nearly the whole country from August to December 2019. DENV NS-1 was detected in 162 samples, among which DENV-specific IgM was positive in 119 samples (73.5%), including 60.5% samples also positive for DENV-specific IgG. Sequencing of the partial <i>C-prM</i> gene and its phylogenetic analysis revealed predominance of DENV type 3 genotype I, accounting for 93% of samples examined. DENV-3 genotype III was identified in two samples from separate districts, and only one DENV-2 cosmopolitan genotype was found in the capital city, Dhaka. These findings suggest the predominance of DENV-3 genotype I and occurrence of DENV-3 genotype III, associated with increased incidence of recent secondary infection in Bangladesh in 2019.https://www.mdpi.com/2414-6366/6/2/58dengue virustype 3genotypeIgMBangladesh |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Snigdha Rahman Titir Shyamal Kumar Paul Salma Ahmed Nazia Haque Syeda Anjuman Nasreen Khondoker Shoaib Hossain Fahim Uddin Ahmad Sultana Shabnam Nila Jobyda Khanam Neaz Nowsher Abu Mohammod Mayeenuddin Al Amin Amdad Ullah Khan Meiji Soe Aung Nobumichi Kobayashi |
spellingShingle |
Snigdha Rahman Titir Shyamal Kumar Paul Salma Ahmed Nazia Haque Syeda Anjuman Nasreen Khondoker Shoaib Hossain Fahim Uddin Ahmad Sultana Shabnam Nila Jobyda Khanam Neaz Nowsher Abu Mohammod Mayeenuddin Al Amin Amdad Ullah Khan Meiji Soe Aung Nobumichi Kobayashi Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh Tropical Medicine and Infectious Disease dengue virus type 3 genotype IgM Bangladesh |
author_facet |
Snigdha Rahman Titir Shyamal Kumar Paul Salma Ahmed Nazia Haque Syeda Anjuman Nasreen Khondoker Shoaib Hossain Fahim Uddin Ahmad Sultana Shabnam Nila Jobyda Khanam Neaz Nowsher Abu Mohammod Mayeenuddin Al Amin Amdad Ullah Khan Meiji Soe Aung Nobumichi Kobayashi |
author_sort |
Snigdha Rahman Titir |
title |
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh |
title_short |
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh |
title_full |
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh |
title_fullStr |
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh |
title_full_unstemmed |
Nationwide Distribution of Dengue Virus Type 3 (DENV-3) Genotype I and Emergence of DENV-3 Genotype III during the 2019 Outbreak in Bangladesh |
title_sort |
nationwide distribution of dengue virus type 3 (denv-3) genotype i and emergence of denv-3 genotype iii during the 2019 outbreak in bangladesh |
publisher |
MDPI AG |
series |
Tropical Medicine and Infectious Disease |
issn |
2414-6366 |
publishDate |
2021-04-01 |
description |
Bangladesh is an endemic region of dengue fever and experienced an unprecedented large outbreak with more than 100,000 confirmed cases in 2019. To understand the prevalence of dengue antibody in patients and molecular epidemiological characteristics of dengue virus (DENV) in this outbreak, a total of 179 blood samples were collected from patients in 10 districts (seven divisions) covering nearly the whole country from August to December 2019. DENV NS-1 was detected in 162 samples, among which DENV-specific IgM was positive in 119 samples (73.5%), including 60.5% samples also positive for DENV-specific IgG. Sequencing of the partial <i>C-prM</i> gene and its phylogenetic analysis revealed predominance of DENV type 3 genotype I, accounting for 93% of samples examined. DENV-3 genotype III was identified in two samples from separate districts, and only one DENV-2 cosmopolitan genotype was found in the capital city, Dhaka. These findings suggest the predominance of DENV-3 genotype I and occurrence of DENV-3 genotype III, associated with increased incidence of recent secondary infection in Bangladesh in 2019. |
topic |
dengue virus type 3 genotype IgM Bangladesh |
url |
https://www.mdpi.com/2414-6366/6/2/58 |
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