Severe Dengue with Hemophagocytosis Syndrome
Dengue is known to cause high morbidity and mortality worldwide. In recent years, there have been increasing cases of dengue fever associated with a rare complication: hemophagocytic syndrome (HPS), which is a dangerous disorder that carries high mortality. It is associated with infections, autoi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academy of Family Physicians of Malaysia
2020-03-01
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| Series: | Malaysian Family Physician |
| Subjects: | |
| Online Access: | https://e-mfp.org/wp-content/uploads/v15n1-case-report-2.pdf |
| Summary: | Dengue is known to cause high morbidity and mortality worldwide. In recent years, there have been
increasing cases of dengue fever associated with a rare complication: hemophagocytic syndrome
(HPS), which is a dangerous disorder that carries high mortality. It is associated with infections,
autoimmune disorders, and malignancies. Prolonged duration of fever and cytopenia together
with multi-organ dysfunction out of proportion to the plasma leakage phase should alert clinicians
to consider this condition. In this case study, we highlight a 45-year-old woman with underlying
diabetes who was admitted due to dengue fever with warning signs. Her conditions deteriorated
quickly: she had spontaneous bleeding, evidence of plasma leakage, severe hepatitis, and coagulopathy
on the 11th day of illness. With the support of other blood results, such as raised serum ferritin and
lactate dehydrogenase, she was diagnosed with severe dengue with hemophagocytosis syndrome. She
responded well to intravenous dexamethasone and recovered on the 19th day of illness. |
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| ISSN: | 1985-2274 1985-207X |