Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications

In biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic t...

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Main Authors:	Hyunil Ryu, Ahmed Fuwad, Sunhee Yoon, Huisoo Jang, Jong Chan Lee, Sun Min Kim, Tae-Joon Jeon
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	International Journal of Molecular Sciences
Subjects:	biomimetic membranes transmembrane proteins aquaporin biosensors DNA sequencing drug screening ATP
Online Access:	https://www.mdpi.com/1422-0067/20/6/1437

id	doaj-9dcec711ef394f9fbdaf3adf2ea58419
record_format	Article
spelling	doaj-9dcec711ef394f9fbdaf3adf2ea584192020-11-24T21:49:07ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206143710.3390/ijms20061437ijms20061437Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein ApplicationsHyunil Ryu0Ahmed Fuwad1Sunhee Yoon2Huisoo Jang3Jong Chan Lee4Sun Min Kim5Tae-Joon Jeon6Department of Biological Engineering, Inha University, Incheon 22212, KoreaBiohybrid Systems Research Center, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaBiohybrid Systems Research Center, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaIn biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic the biological cell environment for transmembrane protein incorporation. The performance and selectivity of these transmembrane proteins based biomimetic platforms are far superior to those of traditional material platforms, but their lack of stability and scalability rule out their commercial presence. This review highlights the development of transmembrane protein-based biomimetic platforms for four major applications, which are biosensors, molecular interaction studies, energy harvesting, and water purification. We summarize the fundamental principles and recent progress in transmembrane protein biomimetic platforms for each application, discuss their limitations, and present future outlooks for industrial implementation.https://www.mdpi.com/1422-0067/20/6/1437biomimetic membranestransmembrane proteinsaquaporinbiosensorsDNA sequencingdrug screeningATP
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon
spellingShingle	Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications International Journal of Molecular Sciences biomimetic membranes transmembrane proteins aquaporin biosensors DNA sequencing drug screening ATP
author_facet	Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon
author_sort	Hyunil Ryu
title	Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
title_short	Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
title_full	Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
title_fullStr	Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
title_full_unstemmed	Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
title_sort	biomimetic membranes with transmembrane proteins: state-of-the-art in transmembrane protein applications
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2019-03-01
description	In biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic the biological cell environment for transmembrane protein incorporation. The performance and selectivity of these transmembrane proteins based biomimetic platforms are far superior to those of traditional material platforms, but their lack of stability and scalability rule out their commercial presence. This review highlights the development of transmembrane protein-based biomimetic platforms for four major applications, which are biosensors, molecular interaction studies, energy harvesting, and water purification. We summarize the fundamental principles and recent progress in transmembrane protein biomimetic platforms for each application, discuss their limitations, and present future outlooks for industrial implementation.
topic	biomimetic membranes transmembrane proteins aquaporin biosensors DNA sequencing drug screening ATP
url	https://www.mdpi.com/1422-0067/20/6/1437
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Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications

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