Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications
In biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic t...
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doaj-9dcec711ef394f9fbdaf3adf2ea584192020-11-24T21:49:07ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206143710.3390/ijms20061437ijms20061437Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein ApplicationsHyunil Ryu0Ahmed Fuwad1Sunhee Yoon2Huisoo Jang3Jong Chan Lee4Sun Min Kim5Tae-Joon Jeon6Department of Biological Engineering, Inha University, Incheon 22212, KoreaBiohybrid Systems Research Center, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaBiohybrid Systems Research Center, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaIn biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic the biological cell environment for transmembrane protein incorporation. The performance and selectivity of these transmembrane proteins based biomimetic platforms are far superior to those of traditional material platforms, but their lack of stability and scalability rule out their commercial presence. This review highlights the development of transmembrane protein-based biomimetic platforms for four major applications, which are biosensors, molecular interaction studies, energy harvesting, and water purification. We summarize the fundamental principles and recent progress in transmembrane protein biomimetic platforms for each application, discuss their limitations, and present future outlooks for industrial implementation.https://www.mdpi.com/1422-0067/20/6/1437biomimetic membranestransmembrane proteinsaquaporinbiosensorsDNA sequencingdrug screeningATP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon |
spellingShingle |
Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications International Journal of Molecular Sciences biomimetic membranes transmembrane proteins aquaporin biosensors DNA sequencing drug screening ATP |
author_facet |
Hyunil Ryu Ahmed Fuwad Sunhee Yoon Huisoo Jang Jong Chan Lee Sun Min Kim Tae-Joon Jeon |
author_sort |
Hyunil Ryu |
title |
Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
title_short |
Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
title_full |
Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
title_fullStr |
Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
title_full_unstemmed |
Biomimetic Membranes with Transmembrane Proteins: State-of-the-Art in Transmembrane Protein Applications |
title_sort |
biomimetic membranes with transmembrane proteins: state-of-the-art in transmembrane protein applications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
In biological cells, membrane proteins are the most crucial component for the maintenance of cell physiology and processes, including ion transportation, cell signaling, cell adhesion, and recognition of signal molecules. Therefore, researchers have proposed a number of membrane platforms to mimic the biological cell environment for transmembrane protein incorporation. The performance and selectivity of these transmembrane proteins based biomimetic platforms are far superior to those of traditional material platforms, but their lack of stability and scalability rule out their commercial presence. This review highlights the development of transmembrane protein-based biomimetic platforms for four major applications, which are biosensors, molecular interaction studies, energy harvesting, and water purification. We summarize the fundamental principles and recent progress in transmembrane protein biomimetic platforms for each application, discuss their limitations, and present future outlooks for industrial implementation. |
topic |
biomimetic membranes transmembrane proteins aquaporin biosensors DNA sequencing drug screening ATP |
url |
https://www.mdpi.com/1422-0067/20/6/1437 |
work_keys_str_mv |
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