SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer
Limitations in current diagnostic procedures warrant identification of new methodologies to improve diagnoses of cancer patients. In this context, long non-coding RNAs (lncRNAs) have emerged as stable biomarkers which are expressed abundantly in tumors. Importantly, these can be detected at all stag...
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doaj-9dd3c7d26e6045afb56440cf97d2a2f32020-11-25T00:44:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-09-01910.3389/fonc.2019.00901470119SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human CancerSuraksha Tamang0Varnali Acharya1Deepronil Roy2Rinka Sharma3Apeksha Aryaa4Uttam Sharma5Akanksha Khandelwal6Hridayesh Prakash7Karen M. Vasquez8Aklank Jain9Department of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Virology and Immunology, Amity University, Noida, IndiaDivision of Pharmacology and Toxicology, Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, Austin, TX, United StatesDepartment of Animal Sciences, Central University of Punjab, Bathinda, IndiaLimitations in current diagnostic procedures warrant identification of new methodologies to improve diagnoses of cancer patients. In this context, long non-coding RNAs (lncRNAs) have emerged as stable biomarkers which are expressed abundantly in tumors. Importantly, these can be detected at all stages of tumor development, and thus may provide potential biomarkers and/or therapeutic targets. Recently, we suggested that aberrant levels of lncRNAs can be used to determine the invasive and metastatic potential of tumor cells. Further, direct correlations of lncRNAs with cancer-derived inflammation, metastasis, epithelial-to-mesenchymal transition, and other hallmarks of cancer indicate their potential as biomarkers and targets for cancer. Thus, in this review we have discussed the importance of small nucleolar RNA host gene 12 (SNHG12), a lncRNA, as a potential biomarker for a variety of cancers. A meta-analysis of a large cohort of cancer patients revealed that SNHG12 may also serve as a potential target for cancer-directed interventions due to its involvement in unfolded protein responses, which many tumor cells exploit to both evade immune-mediated attack and enhance the polarization of effector immune cells (e.g., macrophages and T cells). Thus, we propose that SNHG12 may serve as both a biomarker and a druggable therapeutic target with promising clinical potential.https://www.frontiersin.org/article/10.3389/fonc.2019.00901/fulllong non-coding RNAlncRNASNHG12miRNAcancermicroRNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suraksha Tamang Varnali Acharya Deepronil Roy Rinka Sharma Apeksha Aryaa Uttam Sharma Akanksha Khandelwal Hridayesh Prakash Karen M. Vasquez Aklank Jain |
spellingShingle |
Suraksha Tamang Varnali Acharya Deepronil Roy Rinka Sharma Apeksha Aryaa Uttam Sharma Akanksha Khandelwal Hridayesh Prakash Karen M. Vasquez Aklank Jain SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer Frontiers in Oncology long non-coding RNA lncRNA SNHG12 miRNA cancer microRNA |
author_facet |
Suraksha Tamang Varnali Acharya Deepronil Roy Rinka Sharma Apeksha Aryaa Uttam Sharma Akanksha Khandelwal Hridayesh Prakash Karen M. Vasquez Aklank Jain |
author_sort |
Suraksha Tamang |
title |
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer |
title_short |
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer |
title_full |
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer |
title_fullStr |
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer |
title_full_unstemmed |
SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer |
title_sort |
snhg12: an lncrna as a potential therapeutic target and biomarker for human cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2019-09-01 |
description |
Limitations in current diagnostic procedures warrant identification of new methodologies to improve diagnoses of cancer patients. In this context, long non-coding RNAs (lncRNAs) have emerged as stable biomarkers which are expressed abundantly in tumors. Importantly, these can be detected at all stages of tumor development, and thus may provide potential biomarkers and/or therapeutic targets. Recently, we suggested that aberrant levels of lncRNAs can be used to determine the invasive and metastatic potential of tumor cells. Further, direct correlations of lncRNAs with cancer-derived inflammation, metastasis, epithelial-to-mesenchymal transition, and other hallmarks of cancer indicate their potential as biomarkers and targets for cancer. Thus, in this review we have discussed the importance of small nucleolar RNA host gene 12 (SNHG12), a lncRNA, as a potential biomarker for a variety of cancers. A meta-analysis of a large cohort of cancer patients revealed that SNHG12 may also serve as a potential target for cancer-directed interventions due to its involvement in unfolded protein responses, which many tumor cells exploit to both evade immune-mediated attack and enhance the polarization of effector immune cells (e.g., macrophages and T cells). Thus, we propose that SNHG12 may serve as both a biomarker and a druggable therapeutic target with promising clinical potential. |
topic |
long non-coding RNA lncRNA SNHG12 miRNA cancer microRNA |
url |
https://www.frontiersin.org/article/10.3389/fonc.2019.00901/full |
work_keys_str_mv |
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