Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

• Main Authors: Melinda Barkhuizen, Johan S.H. Vles, Ralph van Mechelen, Marijne Vermeer, Boris W. Kramer, Peter Chedraui, Paul Bergs, Vivianne H.J.M. van Kranen-Mastenbroek, Antonio W.D. Gavilanes
• Format: Article
• Language: English
• Published: MDPI AG 2019-09-01
• Series: Diagnostics
• Subjects: somatosensory evoked potential; preterm brain; rat model; cerebral palsy; hypoxia-ischemia
• Online Access: https://www.mdpi.com/2075-4418/9/3/123

Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.