Validation, Optimization, and Application of the Zebrafish Developmental Toxicity Assay for Pharmaceuticals Under the ICH S5(R3) Guideline

Validation, Optimization, and Application of the Zebrafish Developmental Toxicity Assay for Pharmaceuticals Under the ICH S5(R3) Guideline

The zebrafish as an alternative animal model for developmental toxicity testing has been extensively investigated, but its assay protocol was not harmonized yet. This study has validated and optimized the zebrafish developmental toxicity assay previously reported by multiple inter-laboratory studies...

Full description

Bibliographic Details
Main Authors:	Yi-Sheng Song, Ming-Zhu Dai, Chen-Xia Zhu, Yan-Feng Huang, Jing Liu, Cheng-Da Zhang, Feng Xie, Yi Peng, Yong Zhang, Chun-Qi Li, Li-Jiang Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	zebrafish developmental toxicity teratogenicity malformation embryo-fetal lethality (MEFL) alternative method
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.721130/full

Similar Items

Effect of Tocopheryl Acetate on Maternal Cigarette Smoke Exposed Swiss Albino Mice Inbred Fetus
by: Janardan Chaudhary, et al.
Published: (2016-10-01)

RISK FACTORS IN CHILD CONGENITAL MALFORMATIONS
by: Alina-Costina LUCA, et al.
Published: (2015-04-01)

Eye malformations induced by carbamazepine in Mice
by: Mohammad Afshar (PhD), et al.
Published: (2008-07-01)

Algunas consideraciones actuales sobre las malformaciones en el desarrollo del sistema osteomioarticular
by: Alexi Domínguez Fabars, et al.

"ALTERED PLASMA ZINC LEVEL CONTRIBUTES TO THE DEVELOPMENTAL TOXICITY OF VALPROIC ACID IN SKELETAL SYSTEM OF RAT"
by: M.Akbari1, et al.
Published: (2004-02-01)

"ALTERED PLASMA ZINC LEVEL CONTRIBUTES TO THE DEVELOPMENTAL TOXICITY OF VALPROIC ACID IN SKELETAL SYSTEM OF RAT"
by: M.Akbari1, et al.
Published: (2004-05-01)

Physiological, Developmental, and Biomarker Responses of Zebrafish Embryos to Sub-Lethal Exposure of Bendiocarb
by: Gyöngyi Gazsi, et al.
Published: (2021-01-01)

Propylthiouracil-induced histological changes in the placenta of swiss albino mice
by: Samta Tiwari, et al.
Published: (2020-01-01)

Efek Teratogenik Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Tikus Putih (Rattus norvegicus L.) Galur Winstar
by: SHANTI LISTYAWATI, et al.
Published: (2006-11-01)

Teratogenic effects of Gabapentin on Neural Tube and skeletal development in mice
by: M. Afshar, et al.
Published: (2005-01-01)

Teratogenic, Oxidative Stress and Behavioural Outcomes of Three Fungicides of Natural Origin (<i>Equisetum arvense</i>, <i>Mimosa tenuiflora</i>, Thymol) on Zebrafish (<i>Danio rerio</i>)
by: Raquel Vieira, et al.
Published: (2021-01-01)

Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin α, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development
by: Mehreen Haq, et al.
Published: (2016-02-01)

Teratogenic and Embryotoxic Effects of Polycyclic Aromatic Compounds Report
by: Wagner, Svenja
Published: (2016)

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants
by: Jeffrey T. White, et al.
Published: (2019-03-01)

O USO INADEQUADO DO MISOPROSTOL COMO ABORTIVO: UMA REVISÃO INTEGRATIVA
by: Mariana Fernandes Esteves, et al.
Published: (2021-05-01)

Chemical-Induced Cleft Palate Is Caused and Rescued by Pharmacological Modulation of the Canonical Wnt Signaling Pathway in a Zebrafish Model
by: Rika Narumi, et al.
Published: (2020-12-01)

Zebrafish and Artemia salina in vivo evaluation of the recreational 25C-NBOMe drug demonstrates its high toxicity
by: Natalie Álvarez-Alarcón, et al.
Published: (2021-01-01)

Zebrafish Sensitivity to Botulinum Neurotoxins
by: Kamalakar Chatla, et al.
Published: (2016-05-01)

PARP inhibitor resistance: the underlying mechanisms and clinical implications
by: He Li, et al.
Published: (2020-06-01)

Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos
by: Annalisa Mercurio, et al.
Published: (2019-04-01)

MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?
by: Tingting Zhang, et al.
Published: (2020-05-01)

Aflatoxins in Iran: Nature, Hazards and Carcinogenicity
by: B Khoshpey, et al.
Published: (2011-12-01)

Behavioral response of Panonychus citri (McGregor) (Acari: Tetranychidae) to synthetic chemicals and oils
by: Muhammad Asif Qayyoum, et al.
Published: (2021-04-01)

Experimental and Numerical Investigations of Flow and Solid Transport in Urban Area
by: Zhang, Jiong
Published: (2012)

Aflatoxins in Iran: Nature, Hazards and Carcinogenicity
by: DD Farhud, et al.
Published: (2011-12-01)

Why Do Psychiatrists Still Prescribe Valproate to Women of Childbearing Potential?
by: Aleksei Rakitin
Published: (2020-07-01)

EVALUATION OF EMBRYOTROPIC PROPERTIES OF THE ANTHELMINTIC MITRANOX
by: S. A. Kozlov, et al.
Published: (2016-05-01)

(±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp.
by: Dong-Sheng Deng, et al.
Published: (2013-03-01)

A Review of the Teratogenic Factors Effect on Embryo
by: Manzarbanoo Shojaei fard, et al.
Published: (2017-02-01)

Synthesis and characterization of hesperetin derivatives and toxicity level of the zebrafish model
by: Mani Rajasekar
Published: (2021-01-01)

Phytochemical and Safety Evaluations of <i>Zingiber ottensii</i> Valeton Essential Oil in Zebrafish Embryos and Rats
by: Wisit Thitinarongwate, et al.
Published: (2021-05-01)

New Prediction Models of Functional Outcome in Acute Intracerebral Hemorrhage: The dICH Score and uICH Score
by: Wen-Song Yang, et al.
Published: (2021-05-01)

From the Farm to the Lab: How Chicken Embryos Contribute to the Field of Teratology
by: Gabriela Elis Wachholz, et al.
Published: (2021-07-01)

Varicocele due to renal arteriovenous malformation mimicking a renal tumor: a case report
by: Peng-chao Li, et al.
Published: (2018-01-01)

Surgical treatment of Chiari malformation: review and progress
by: Peng⁃chao LI, et al.
Published: (2012-08-01)

Comparative safety of asthma treatment regimens during pregnancy and related methodological aspects
by: Eltonsy, Sherif
Published: (2017)

Distribution of pomalidomide into semen of healthy male subjects after multiple doses
by: Li Y, et al.
Published: (2018-05-01)

Influence of total dissolved gas-supersaturated water on silver carp (Hypophthalmichthys molitrix)
by: Lu Cao, et al.
Published: (2016-10-01)

Gene-teratogen interaction in insulin-induced mouse exencephaly
by: Cole, Wendy Anne
Published: (1978)

Collaborative Response of the Host and Symbiotic Lignocellulytic System to Non-Lethal Toxic Stress in <i>Coptotermes formosanus</i> Skiraki
by: Wenhui Zeng, et al.
Published: (2021-05-01)