Validation, Optimization, and Application of the Zebrafish Developmental Toxicity Assay for Pharmaceuticals Under the ICH S5(R3) Guideline
The zebrafish as an alternative animal model for developmental toxicity testing has been extensively investigated, but its assay protocol was not harmonized yet. This study has validated and optimized the zebrafish developmental toxicity assay previously reported by multiple inter-laboratory studies...
Main Authors: | Yi-Sheng Song, Ming-Zhu Dai, Chen-Xia Zhu, Yan-Feng Huang, Jing Liu, Cheng-Da Zhang, Feng Xie, Yi Peng, Yong Zhang, Chun-Qi Li, Li-Jiang Zhang |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-09-01
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Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.721130/full |
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