Micro Optical Coherence Tomography for Coronary Imaging
Intravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This is...
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2021-03-01
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doaj-9de8671c0cbc449e955aaab09637c09c2021-03-26T04:19:56ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-03-01810.3389/fcvm.2021.613400613400Micro Optical Coherence Tomography for Coronary ImagingKensuke Nishimiya0Kensuke Nishimiya1Guillermo Tearney2Guillermo Tearney3Guillermo Tearney4Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Pathology, Massachusetts General Hospital, Boston, MA, United StatesHarvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology Division, Cambridge, MA, United StatesIntravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This issue has motivated the development of a next-generation form of OCT imaging that offers higher resolution. One such technology that we review here is termed micro-OCT (μOCT) that enables the assessment of the cellular and subcellular morphology of human coronary atherosclerotic plaques. This chapter reviews recent advances and ongoing works regarding μOCT in the field of cardiology. This new technology has the potential to provide researchers and clinicians with a tool to better understand the natural history of coronary atherosclerosis, increase plaque progression prediction capabilities, and better assess the vessel healing process after revascularization therapy.https://www.frontiersin.org/articles/10.3389/fcvm.2021.613400/fulloptical coherence tomographymicro-OCTendothelial cellsinflammatory cellsmacrophage—cellcholesterol crystals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kensuke Nishimiya Kensuke Nishimiya Guillermo Tearney Guillermo Tearney Guillermo Tearney |
spellingShingle |
Kensuke Nishimiya Kensuke Nishimiya Guillermo Tearney Guillermo Tearney Guillermo Tearney Micro Optical Coherence Tomography for Coronary Imaging Frontiers in Cardiovascular Medicine optical coherence tomography micro-OCT endothelial cells inflammatory cells macrophage—cell cholesterol crystals |
author_facet |
Kensuke Nishimiya Kensuke Nishimiya Guillermo Tearney Guillermo Tearney Guillermo Tearney |
author_sort |
Kensuke Nishimiya |
title |
Micro Optical Coherence Tomography for Coronary Imaging |
title_short |
Micro Optical Coherence Tomography for Coronary Imaging |
title_full |
Micro Optical Coherence Tomography for Coronary Imaging |
title_fullStr |
Micro Optical Coherence Tomography for Coronary Imaging |
title_full_unstemmed |
Micro Optical Coherence Tomography for Coronary Imaging |
title_sort |
micro optical coherence tomography for coronary imaging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-03-01 |
description |
Intravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This issue has motivated the development of a next-generation form of OCT imaging that offers higher resolution. One such technology that we review here is termed micro-OCT (μOCT) that enables the assessment of the cellular and subcellular morphology of human coronary atherosclerotic plaques. This chapter reviews recent advances and ongoing works regarding μOCT in the field of cardiology. This new technology has the potential to provide researchers and clinicians with a tool to better understand the natural history of coronary atherosclerosis, increase plaque progression prediction capabilities, and better assess the vessel healing process after revascularization therapy. |
topic |
optical coherence tomography micro-OCT endothelial cells inflammatory cells macrophage—cell cholesterol crystals |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.613400/full |
work_keys_str_mv |
AT kensukenishimiya microopticalcoherencetomographyforcoronaryimaging AT kensukenishimiya microopticalcoherencetomographyforcoronaryimaging AT guillermotearney microopticalcoherencetomographyforcoronaryimaging AT guillermotearney microopticalcoherencetomographyforcoronaryimaging AT guillermotearney microopticalcoherencetomographyforcoronaryimaging |
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