Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation

Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation

Herein we report the synthesis of some new 1<i>H</i>-1,2,4-triazole functionalized chromenols (<b>3a</b>–<b>3n</b>) via tandem reactions of 1-(alkyl/aryl)-2-(1<i>H</i>-1,2,4-triazole-1-yl) with salicylic aldehydes and the evaluation of their antifungal...

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Bibliographic Details
Main Authors: Marina Zveaghintseva, Eugenia Stingaci, Serghei Pogrebnoi, Anastasia Smetanscaia, Vladimir Valica, Livia Uncu, Victor Ch. Kravtsov, Elena Melnic, Anthi Petrou, Jasmina Glamočlija, Marina Soković, Alejandro Carazo, Přemysl Mladěnka, Vladimir Poroikov, Athina Geronikaki, Fliur Z. Macaev
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
vinyl-1,2,4-triazole
chromenol
antifungal activity
<i>C. albicans</i> CYP51
PASS
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/14/4304

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