Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer
MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation...
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doaj-9e108679e685404b973a0ac6a4f6b0222020-11-25T03:24:47ZengMDPI AGNon-Coding RNA2311-553X2020-07-016292910.3390/ncrna6030029Potential miRNAs for miRNA-Based Therapeutics in Breast CancerJun Sheng Wong0Yoke Kqueen Cheah1Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaMicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications.https://www.mdpi.com/2311-553X/6/3/29breast cancermicroRNAscell linemiRNA-based therapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Sheng Wong Yoke Kqueen Cheah |
spellingShingle |
Jun Sheng Wong Yoke Kqueen Cheah Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer Non-Coding RNA breast cancer microRNAs cell line miRNA-based therapeutics |
author_facet |
Jun Sheng Wong Yoke Kqueen Cheah |
author_sort |
Jun Sheng Wong |
title |
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer |
title_short |
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer |
title_full |
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer |
title_fullStr |
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer |
title_full_unstemmed |
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer |
title_sort |
potential mirnas for mirna-based therapeutics in breast cancer |
publisher |
MDPI AG |
series |
Non-Coding RNA |
issn |
2311-553X |
publishDate |
2020-07-01 |
description |
MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications. |
topic |
breast cancer microRNAs cell line miRNA-based therapeutics |
url |
https://www.mdpi.com/2311-553X/6/3/29 |
work_keys_str_mv |
AT junshengwong potentialmirnasformirnabasedtherapeuticsinbreastcancer AT yokekqueencheah potentialmirnasformirnabasedtherapeuticsinbreastcancer |
_version_ |
1724599914773610496 |