Plasma cytokine levels before and 1 year after successful living-donor renal transplantation

• Main Authors: Ayato Ito, Jun Sugimura, Tomohiko Matsuura, Takaya Abe, Wataru Obara
• Format: Article
• Language: English
• Published: BMC 2020-11-01
• Series: Renal Replacement Therapy
• Subjects: Cytokine; Renal transplantation; Chronic rejection; Uremia; Dialysis
• Online Access: http://link.springer.com/article/10.1186/s41100-020-00298-5

Abstract Purpose This study aimed to evaluate cytokine levels in plasma samples over time from living-donor renal transplant recipients with no evidence of pathological and clinical rejection at least 1 year post-procedure. Methods We examined plasma cytokine levels in 15 living-donor renal transplant recipients who were treated at our hospital from 2015 to 2018 and who presented with no evidence of pathological or clinical rejection for 1 year or longer. We collected blood samples before renal transplantation and at 1 week and 1 year post-procedure. We evaluated levels of 40 cytokines in plasma using Bio-Plex Pro™ Human Chemokine Assay kit. Results We detected no increase in plasma cytokine levels at either the 1 week or the 1 year time points. Plasma levels of 22 cytokines remained stable throughout and levels of 18 cytokine decreased after transplantation. Conclusion Plasma cytokine levels remained unchanged or were decreased in our patient cohort that included stable cases of living-donor renal transplantation. Our results suggest that renal transplantation may promote amelioration of chronic inflammation associated with end-stage renal failure and dialysis.