Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study

<p>Abstract</p> <p>Background</p> <p>While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention.</p> <p>Methods</p> <p>We conducted a popu...

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Main Authors: Paddock Lisa E, Chandran Urmila, King Melony, Bandera Elisa V, Rodriguez-Rodriguez Lorna, Olson Sara H
Format: Article
Language:English
Published: BMC 2011-09-01
Series:BMC Women's Health
Online Access:http://www.biomedcentral.com/1472-6874/11/40
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spelling doaj-9e1b8b85c74e4304a2de9e2bf712b9e92020-11-25T01:04:43ZengBMCBMC Women's Health1472-68742011-09-011114010.1186/1472-6874-11-40Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control studyPaddock Lisa EChandran UrmilaKing MelonyBandera Elisa VRodriguez-Rodriguez LornaOlson Sara H<p>Abstract</p> <p>Background</p> <p>While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention.</p> <p>Methods</p> <p>We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were included in analyses. Unconditional logistic regression analyses were conducted to examine associations with total phytoestrogens, as well as isoflavones (daidzein, genistein, formononetin, and glycitein), lignans (matairesinol, lariciresinol, pinoresinol, secoisolariciresinol), and coumestrol.</p> <p>Results</p> <p>No statistically significant associations were found with any of the phytoestrogens under evaluation. However, there was a suggestion of an inverse association with total phytoestrogen consumption (from foods and supplements), with an odds ratio (OR) of 0.62 (95% CI: 0.38-1.00; p for trend: 0.04) for the highest vs. lowest tertile of consumption, after adjusting for reproductive covariates, age, race, education, BMI, and total energy. Further adjustment for smoking and physical activity attenuated risk estimates (OR: 0.66; 95% CI: 0.41-1.08). There was little evidence of an inverse association for isoflavones, lignans, or coumestrol.</p> <p>Conclusions</p> <p>This study provided some suggestion that phytoestrogen consumption may decrease ovarian cancer risk, although results did not reach statistical significance.</p> http://www.biomedcentral.com/1472-6874/11/40
collection DOAJ
language English
format Article
sources DOAJ
author Paddock Lisa E
Chandran Urmila
King Melony
Bandera Elisa V
Rodriguez-Rodriguez Lorna
Olson Sara H
spellingShingle Paddock Lisa E
Chandran Urmila
King Melony
Bandera Elisa V
Rodriguez-Rodriguez Lorna
Olson Sara H
Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
BMC Women's Health
author_facet Paddock Lisa E
Chandran Urmila
King Melony
Bandera Elisa V
Rodriguez-Rodriguez Lorna
Olson Sara H
author_sort Paddock Lisa E
title Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
title_short Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
title_full Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
title_fullStr Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
title_full_unstemmed Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
title_sort phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
publisher BMC
series BMC Women's Health
issn 1472-6874
publishDate 2011-09-01
description <p>Abstract</p> <p>Background</p> <p>While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention.</p> <p>Methods</p> <p>We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were included in analyses. Unconditional logistic regression analyses were conducted to examine associations with total phytoestrogens, as well as isoflavones (daidzein, genistein, formononetin, and glycitein), lignans (matairesinol, lariciresinol, pinoresinol, secoisolariciresinol), and coumestrol.</p> <p>Results</p> <p>No statistically significant associations were found with any of the phytoestrogens under evaluation. However, there was a suggestion of an inverse association with total phytoestrogen consumption (from foods and supplements), with an odds ratio (OR) of 0.62 (95% CI: 0.38-1.00; p for trend: 0.04) for the highest vs. lowest tertile of consumption, after adjusting for reproductive covariates, age, race, education, BMI, and total energy. Further adjustment for smoking and physical activity attenuated risk estimates (OR: 0.66; 95% CI: 0.41-1.08). There was little evidence of an inverse association for isoflavones, lignans, or coumestrol.</p> <p>Conclusions</p> <p>This study provided some suggestion that phytoestrogen consumption may decrease ovarian cancer risk, although results did not reach statistical significance.</p>
url http://www.biomedcentral.com/1472-6874/11/40
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