Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid

Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause recurring bacterial infection in CF patients' lungs. However, the severity of CF lung disease correlates poorly with genotype. Antibiotic treatment helps dramatically prolong patients' life. The lung disease...

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Bibliographic Details
Main Authors: Yajamana Ramu, Yanping Xu, Hyeon-Gyu Shin, Zhe Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
potassium channel
CFTR
phospholipase
sphingomyelinase
toxin
channel inhibition
Online Access:https://elifesciences.org/articles/03683

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