Effect of Qingguang'an on elastic fiber, MMP-7, TIMP-1 in scarring area of filtration canal after glaucoma surgery

• Main Authors: Yuan-Bi Li, Qing-Hua Peng, Xue-Si Huang, Xiao-Liu Chen, Han-Yu Tan
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2015-01-01
• Series: Guoji Yanke Zazhi
• Subjects: glaucoma; scarring area of filtration canal; elastic fiber; MMP-7; TIMP-1
• Online Access: http://ies.ijo.cn/cn_publish/2015/1/201501005.pdf

AIM: To observe the effect of Qingguang'an on elastic fiber, MMP-7, TIMP-1 in scarring area of filtration canal after glaucoma surgery through the four Qingguang'an effective groups and Qingguang'an granules, to discuss and compare their mechanism of action on scarring area of filtration canal.<p>METHODS:Four effective components of Qingguang'an were used in groups D, E, F, G and H after glaucoma surgery, compared with group A(blank), group B(model)and group C(MMC)to observe the effect of elastic fiber, MMP-7, TIMP-1 in scarring filtration canal.<p>RESULTS:Compared with the preoperative basic IOP and 2d, 1, 2, 4wk postoperative IOP of groups C, E and H, the IOP of three group rose up slower than other groups, and kept the lowest data at 28d. There was significant difference compared with the rest of A, B, D, F, G groups(<i>P</i><0.05). The area and density of elastic fiber in surgery group were significantly different with that of black control group(<i>P</i><0.05), but there were no statistical differences between groups C and H, groups C and F, groups H and E(<i>P</i>>0.05). The difference was statistically significant among other groups(<i>P</i><0.01).<p>CONCLUSION:The scarring area of filtration canal after glaucoma surgery is the major reason which lead to the failure of surgery. Qingguang'an effective group 2, Qingguang'an granules and MMC could reduced the scar tissue by restrained the elastic fiber, TIMP-1 and increased the MMP-7. By observing the experimental results that both Qingguang'an effective group 2 and Qingguang'an granules could restrained the scarring area of filtration canal, the effects were unbiased, Qingguang'an granules group is better than effective group 2.