What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human Radiosensitivity

What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human Radiosensitivity

Our understanding of the molecular and cellular response to ionizing radiation (IR) has progressed considerably. This is notably the case for the repair and signaling of DNA double-strand breaks (DSB) that, if unrepaired, can result in cell lethality, or if misrepaired, can cause cancer. However, th...

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Bibliographic Details
Main Authors: Elise Berthel, Mélanie L. Ferlazzo, Clément Devic, Michel Bourguignon, Nicolas Foray
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
dna double-strand breaks
dsb repair
non-homologous end-joining
radiation
radiosensitivity
Online Access:https://www.mdpi.com/1422-0067/20/21/5339

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