Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen

Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen

Infections due to carbapenemase-producing Klebsiella pneumoniae represent an emerging threat due to the high mortality rate and lack of valid antimicrobial combinations, especially when the strain is colistin-resistant. We report a case of bloodstream infection due to pandrug-resistant K. pneumonia...

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Main Authors: Alessandra Oliva, Maria T. Mascellino, Alessia Cipolla, Alessandra D’Abramo, Annalisa De Rosa, Stefano Savinelli, Maria Rosa Ciardi, Claudio M. Mastroianni, Vincenzo Vullo
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:International Journal of Infectious Diseases
Subjects:
Double carbapenem
Colistin
Pan-drug resistant K. pneumoniae
Bloodstream infection
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971215000168
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spelling doaj-9e29b58bf60b466eb82d03ced9eb0f432020-11-24T21:24:40ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C13213410.1016/j.ijid.2015.01.011Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimenAlessandra Oliva0Maria T. Mascellino1Alessia Cipolla2Alessandra D’Abramo3Annalisa De Rosa4Stefano Savinelli5Maria Rosa Ciardi6Claudio M. Mastroianni7Vincenzo Vullo8Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Piazzale Aldo Moro, 00185 Rome, Italy Infections due to carbapenemase-producing Klebsiella pneumoniae represent an emerging threat due to the high mortality rate and lack of valid antimicrobial combinations, especially when the strain is colistin-resistant. We report a case of bloodstream infection due to pandrug-resistant K. pneumoniae treated successfully with an innovative regimen comprising a combination of colistin plus double carbapenem, along with an in vitro analysis showing the synergistic and bactericidal effect. http://www.sciencedirect.com/science/article/pii/S1201971215000168Double carbapenemColistinPan-drug resistant K. pneumoniaeBloodstream infection
collection DOAJ
language English
format Article
sources DOAJ
author Alessandra Oliva
Maria T. Mascellino
Alessia Cipolla
Alessandra D’Abramo
Annalisa De Rosa
Stefano Savinelli
Maria Rosa Ciardi
Claudio M. Mastroianni
Vincenzo Vullo
spellingShingle Alessandra Oliva
Maria T. Mascellino
Alessia Cipolla
Alessandra D’Abramo
Annalisa De Rosa
Stefano Savinelli
Maria Rosa Ciardi
Claudio M. Mastroianni
Vincenzo Vullo
Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
International Journal of Infectious Diseases
Double carbapenem
Colistin
Pan-drug resistant K. pneumoniae
Bloodstream infection
author_facet Alessandra Oliva
Maria T. Mascellino
Alessia Cipolla
Alessandra D’Abramo
Annalisa De Rosa
Stefano Savinelli
Maria Rosa Ciardi
Claudio M. Mastroianni
Vincenzo Vullo
author_sort Alessandra Oliva
title Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
title_short Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
title_full Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
title_fullStr Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
title_full_unstemmed Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
title_sort therapeutic strategy for pandrug-resistant klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
1878-3511
publishDate 2015-04-01
description Infections due to carbapenemase-producing Klebsiella pneumoniae represent an emerging threat due to the high mortality rate and lack of valid antimicrobial combinations, especially when the strain is colistin-resistant. We report a case of bloodstream infection due to pandrug-resistant K. pneumoniae treated successfully with an innovative regimen comprising a combination of colistin plus double carbapenem, along with an in vitro analysis showing the synergistic and bactericidal effect.
topic Double carbapenem
Colistin
Pan-drug resistant K. pneumoniae
Bloodstream infection
url http://www.sciencedirect.com/science/article/pii/S1201971215000168
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