A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.

A novel chitosan-γPGA polyelectrolyte complex hydrogel (C-PGA) has been developed and proven to be an effective dressing for wound healing. The purpose of this study was to evaluate if C-PGA could promote new bone formation in the alveolar socket following tooth extraction. An animal model was propo...

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Main Authors: Hao-Hueng Chang, Yin-Lin Wang, Yu-Chih Chiang, Yen-Liang Chen, Yu-Horng Chuang, Shang-Jye Tsai, Kuo-Huang Heish, Feng-Huei Lin, Chun-Pin Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3962413?pdf=render
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spelling doaj-9e3429863595495d9b39cb9ecd556d9c2020-11-25T02:51:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9236210.1371/journal.pone.0092362A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.Hao-Hueng ChangYin-Lin WangYu-Chih ChiangYen-Liang ChenYu-Horng ChuangShang-Jye TsaiKuo-Huang HeishFeng-Huei LinChun-Pin LinA novel chitosan-γPGA polyelectrolyte complex hydrogel (C-PGA) has been developed and proven to be an effective dressing for wound healing. The purpose of this study was to evaluate if C-PGA could promote new bone formation in the alveolar socket following tooth extraction. An animal model was proposed using radiography and histomorphology simultaneously to analyze the symmetrical sections of Wistar rats. The upper incisors of Wistar rats were extracted and the extraction sockets were randomly treated with gelatin sponge, neat chitosan, C-PGA, or received no treatment. The extraction sockets of selected rats from each group were evaluated at 1, 2, 4, or 6 wk post-extraction. The results of radiography and histopathology indicated that the extraction sockets treated with C-PGA exhibited lamellar bone formation (6.5%) as early as 2 wk after the extraction was performed. Moreover, the degree of new bone formation was significantly higher (P < 0.05) in the extraction sockets treated with C-PGA at 6 wk post-extraction than that in the other study groups. In this study, we demonstrated that the proposed animal model involving symmetrical sections and simultaneous radiography and histomorphology evaluation is feasible. We also conclude that the novel C-PGA has great potential for new bone formation in the alveolar socket following tooth extraction.http://europepmc.org/articles/PMC3962413?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Hao-Hueng Chang
Yin-Lin Wang
Yu-Chih Chiang
Yen-Liang Chen
Yu-Horng Chuang
Shang-Jye Tsai
Kuo-Huang Heish
Feng-Huei Lin
Chun-Pin Lin
spellingShingle Hao-Hueng Chang
Yin-Lin Wang
Yu-Chih Chiang
Yen-Liang Chen
Yu-Horng Chuang
Shang-Jye Tsai
Kuo-Huang Heish
Feng-Huei Lin
Chun-Pin Lin
A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
PLoS ONE
author_facet Hao-Hueng Chang
Yin-Lin Wang
Yu-Chih Chiang
Yen-Liang Chen
Yu-Horng Chuang
Shang-Jye Tsai
Kuo-Huang Heish
Feng-Huei Lin
Chun-Pin Lin
author_sort Hao-Hueng Chang
title A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
title_short A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
title_full A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
title_fullStr A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
title_full_unstemmed A novel chitosan-γPGA polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
title_sort novel chitosan-γpga polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description A novel chitosan-γPGA polyelectrolyte complex hydrogel (C-PGA) has been developed and proven to be an effective dressing for wound healing. The purpose of this study was to evaluate if C-PGA could promote new bone formation in the alveolar socket following tooth extraction. An animal model was proposed using radiography and histomorphology simultaneously to analyze the symmetrical sections of Wistar rats. The upper incisors of Wistar rats were extracted and the extraction sockets were randomly treated with gelatin sponge, neat chitosan, C-PGA, or received no treatment. The extraction sockets of selected rats from each group were evaluated at 1, 2, 4, or 6 wk post-extraction. The results of radiography and histopathology indicated that the extraction sockets treated with C-PGA exhibited lamellar bone formation (6.5%) as early as 2 wk after the extraction was performed. Moreover, the degree of new bone formation was significantly higher (P < 0.05) in the extraction sockets treated with C-PGA at 6 wk post-extraction than that in the other study groups. In this study, we demonstrated that the proposed animal model involving symmetrical sections and simultaneous radiography and histomorphology evaluation is feasible. We also conclude that the novel C-PGA has great potential for new bone formation in the alveolar socket following tooth extraction.
url http://europepmc.org/articles/PMC3962413?pdf=render
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