Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease

• Main Author: O.I. Kadykova
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2016-02-01
• Series: Mìžnarodnij Endokrinologìčnij Žurnal
• Subjects: Gln27Glu polymorphism of β2-adrenergic receptors gene; ischemic heart disease; obesity; carbohydrate and lipid metabolism.
• Online Access: http://iej.zaslavsky.com.ua/article/view/71096

This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease. A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study determined the carbohydrate, lipid metabolism and gene allelic polymorphism of Gln27Glu of β2-adrenergic receptors gene. Comorbidity of ischemic heart disease and obesity is characterized by hyperinsulinemia and insulin resistance on the background of normoglycemia that is associated with the G/G genotype polymorphism of Gln27Glu of β2-adrenergic receptors gene. G/G genotype polymorphism gene of Gln27Glu β2-adrenergic receptors in patients with ischemic heart disease is associated with increased body mass index and triglyceride levels. In our study, we provided evidence of the influence of genotype G/G of Gln27Glu polymorphism of β2-adrenergic receptors gene in patients with ischemic heart disease and obesity on carbohydrate and lipid metabolism. Homozygotes (G/G) had elevated insulin levels, insulin resistance, body mass index and triglycerides.