Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease
This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease. A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study d...
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doaj-9e3821121e8d4d898dad12550c4a6e302020-11-24T22:58:54ZengPublishing House ZaslavskyMìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272016-02-01121.73929610.22141/2224-0721.1.73.2016.7109671096Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart DiseaseO.I. Kadykova0Kharkiv National Medical University, Kharkiv, UkraineThis article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease. A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study determined the carbohydrate, lipid metabolism and gene allelic polymorphism of Gln27Glu of β2-adrenergic receptors gene. Comorbidity of ischemic heart disease and obesity is characterized by hyperinsulinemia and insulin resistance on the background of normoglycemia that is associated with the G/G genotype polymorphism of Gln27Glu of β2-adrenergic receptors gene. G/G genotype polymorphism gene of Gln27Glu β2-adrenergic receptors in patients with ischemic heart disease is associated with increased body mass index and triglyceride levels. In our study, we provided evidence of the influence of genotype G/G of Gln27Glu polymorphism of β2-adrenergic receptors gene in patients with ischemic heart disease and obesity on carbohydrate and lipid metabolism. Homozygotes (G/G) had elevated insulin levels, insulin resistance, body mass index and triglycerides.http://iej.zaslavsky.com.ua/article/view/71096Gln27Glu polymorphism of β2-adrenergic receptors geneischemic heart diseaseobesitycarbohydrate and lipid metabolism. |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
O.I. Kadykova |
spellingShingle |
O.I. Kadykova Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease Mìžnarodnij Endokrinologìčnij Žurnal Gln27Glu polymorphism of β2-adrenergic receptors gene ischemic heart disease obesity carbohydrate and lipid metabolism. |
author_facet |
O.I. Kadykova |
author_sort |
O.I. Kadykova |
title |
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease |
title_short |
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease |
title_full |
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease |
title_fullStr |
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease |
title_full_unstemmed |
Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease |
title_sort |
snps gln27glu polymorphism of β2-adrenoceptor gene and carbohydrate and lipid metabolism impairment in obese patients with ischemic heart disease |
publisher |
Publishing House Zaslavsky |
series |
Mìžnarodnij Endokrinologìčnij Žurnal |
issn |
2224-0721 2307-1427 |
publishDate |
2016-02-01 |
description |
This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease.
A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study determined the carbohydrate, lipid metabolism and gene allelic polymorphism of Gln27Glu of β2-adrenergic receptors gene.
Comorbidity of ischemic heart disease and obesity is characterized by hyperinsulinemia and insulin resistance on the background of normoglycemia that is associated with the G/G genotype polymorphism of Gln27Glu of β2-adrenergic receptors gene. G/G genotype polymorphism gene of Gln27Glu β2-adrenergic receptors in patients with ischemic heart disease is associated with increased body mass index and triglyceride levels.
In our study, we provided evidence of the influence of genotype G/G of Gln27Glu polymorphism of β2-adrenergic receptors gene in patients with ischemic heart disease and obesity on carbohydrate and lipid metabolism. Homozygotes (G/G) had elevated insulin levels, insulin resistance, body mass index and triglycerides. |
topic |
Gln27Glu polymorphism of β2-adrenergic receptors gene ischemic heart disease obesity carbohydrate and lipid metabolism. |
url |
http://iej.zaslavsky.com.ua/article/view/71096 |
work_keys_str_mv |
AT oikadykova snpsgln27glupolymorphismofb2adrenoceptorgeneandcarbohydrateandlipidmetabolismimpairmentinobesepatientswithischemicheartdisease |
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