| Summary: | <i>Fusarium</i> wilt of potato is one of the most common diseases of potato in China, and is becoming a serious threat in potato production. It has been reported that osthole from <i>Cnidium monnieri</i> (<i>L.</i>) <i>Cusson</i> can inhibit plant pathogens. Here, we test the anti-fungal activity of <i>C. monnieri</i> osthole against <i>Fusarium oxysporum</i> in potatoes. The results showed that at a concentration of 5 mg/mL, osthole was able to obviously inhibit mycelial growth of <i>F. oxysporum</i>. We found that osthole caused changes of mycelial morphology, notably hyphal swelling and darkening. Osthole significantly reduced the spore germination of <i>Fusarium</i> by 57.40%. In addition, osthole also inhibited the growth of other pathogens such as <i>Fusarium moniliforme</i> J. Sheld, <i>Thanatephorus cucumeris</i> Donk, and <i>Alternaria alternata</i> (Fr.) Keissl, but not <i>Alternaria solani</i> Jonesetgrout and <i>Valsa mali</i> Miyabe and G. Yamada. Our results suggest that osthole has considerable potential as an agent for the prevention and treatment of potato <i>Fusarium</i> wilt.
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