Fitness costs of mutations at the HIV-1 capsid hexamerization interface.
The recently available x-ray crystal structure of HIV-1 capsid hexamers has provided insight into the molecular interactions crucial for the virus's mature capsid formation. Amino acid changes at these interaction points are likely to have a strong impact on capsid functionality and, hence, vir...
Main Authors: | Siriphan Manocheewa, J Victor Swain, Erinn Lanxon-Cookson, Morgane Rolland, James I Mullins |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3681919?pdf=render |
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