GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer
IDO1-mediated immune escape can lead to the malignant progression of tumors. However, the precise mechanism of IDO1 remains unclear. This study showed that IDO1 can bind to GBP1 and increase the extracellular secretion of IDO1 with the assistance of GBP1, thereby promoting the malignant proliferatio...
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doaj-9e50e2bcccb0451abac16001865cc0862021-01-20T14:41:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-01-011110.3389/fimmu.2020.622467622467GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung CancerYinnan Meng0Wei Wang1Meng Chen2Kuifei Chen3Xinhang Xia4Suna Zhou5Haihua Yang6Haihua Yang7Laboratory of Cellular and Molecular Radiation Oncology, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, ChinaLaboratory of Cellular and Molecular Radiation Oncology, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, ChinaSchool of Medicine, Shaoxing University, Shaoxing, ChinaSchool of Medicine, Shaoxing University, Shaoxing, ChinaLaboratory of Cellular and Molecular Radiation Oncology, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, ChinaLaboratory of Cellular and Molecular Radiation Oncology, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, ChinaLaboratory of Cellular and Molecular Radiation Oncology, Radiation Oncology Institute of Enze Medical Health Academy, Department of Radiation Oncology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, ChinaSchool of Medicine, Shaoxing University, Shaoxing, ChinaIDO1-mediated immune escape can lead to the malignant progression of tumors. However, the precise mechanism of IDO1 remains unclear. This study showed that IDO1 can bind to GBP1 and increase the extracellular secretion of IDO1 with the assistance of GBP1, thereby promoting the malignant proliferation and metastasis of lung cancer. In vitro study showed that the high expression levels of IDO1 and GBP1 in lung cancer cells promoted cell invasion and migration. In vivo study revealed that knock-down of IDO1 and GBP1 inhibited tumor growth and metastasis. In addition, Astragaloside IV reduces the extracellular secretion of IDO1 by blocking the interaction of IDO1 and GBP1, thereby reducing T cell exhaustion and inhibiting tumor progression. These results suggest that blocking the extracellular secretion of IDO1 may prevent T cell exhaustion and thereby enhance the effect of PD-1 inhibitors on cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2020.622467/fulllung cancerindoleamine 2,3-dioxygenase 1 (IDO1)GBP1PD-1astragaloside IV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yinnan Meng Wei Wang Meng Chen Kuifei Chen Xinhang Xia Suna Zhou Haihua Yang Haihua Yang |
spellingShingle |
Yinnan Meng Wei Wang Meng Chen Kuifei Chen Xinhang Xia Suna Zhou Haihua Yang Haihua Yang GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer Frontiers in Immunology lung cancer indoleamine 2,3-dioxygenase 1 (IDO1) GBP1 PD-1 astragaloside IV |
author_facet |
Yinnan Meng Wei Wang Meng Chen Kuifei Chen Xinhang Xia Suna Zhou Haihua Yang Haihua Yang |
author_sort |
Yinnan Meng |
title |
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer |
title_short |
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer |
title_full |
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer |
title_fullStr |
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer |
title_full_unstemmed |
GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer |
title_sort |
gbp1 facilitates indoleamine 2,3-dioxygenase extracellular secretion to promote the malignant progression of lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-01-01 |
description |
IDO1-mediated immune escape can lead to the malignant progression of tumors. However, the precise mechanism of IDO1 remains unclear. This study showed that IDO1 can bind to GBP1 and increase the extracellular secretion of IDO1 with the assistance of GBP1, thereby promoting the malignant proliferation and metastasis of lung cancer. In vitro study showed that the high expression levels of IDO1 and GBP1 in lung cancer cells promoted cell invasion and migration. In vivo study revealed that knock-down of IDO1 and GBP1 inhibited tumor growth and metastasis. In addition, Astragaloside IV reduces the extracellular secretion of IDO1 by blocking the interaction of IDO1 and GBP1, thereby reducing T cell exhaustion and inhibiting tumor progression. These results suggest that blocking the extracellular secretion of IDO1 may prevent T cell exhaustion and thereby enhance the effect of PD-1 inhibitors on cancer treatment. |
topic |
lung cancer indoleamine 2,3-dioxygenase 1 (IDO1) GBP1 PD-1 astragaloside IV |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.622467/full |
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